Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-12-24
1999-03-09
Patterson, Jr., Charles L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435194, 536 232, A61K 3170
Patent
active
058801057
ABSTRACT:
This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.
REFERENCES:
Stambolian, et al., "Purification of Human Galactokinase and Evidence For Its Existence as a Monomer Form", (1985), Biochimica Biophysica Acta, 831:306-312.
Lee, et al., "Cloning of a Human Galactokinase Gene (GK2) on Chromosome 15 By Complementation in Yeast", (1992), Proc. Natl. Acad. Sci, USA, 89:10887-10891.
Debouck, et al., "Structure of the Galactokinase Gene of Escherichia coli, the Last (?) Gene of the gal Operon", (1985), Nucl. Acids Research, 13:1841-1853.
Glaser, et al., "Bacillus subtilis Genome Project: Cloning and Sequencing of the 97 kb Region From 325.degree. to 333.degree.", (1993), Molecular Microbiology, 10:371-384.
Houng, et al., "Molecular Cloning and Physical and Functional Characterization of the Salmonella typhimurium and Salmonella typhi Galactose Utilization Operons", (1990), Journal of Bacteriology, 172:4392-4398.
Bergsma Derk Jon
Rosen Craig A.
Ruben Steven M.
Stambolian Dwight Edward
Eagle Alissa M.
King William T.
Patterson Jr. Charles L.
SmithKline Beecham Corporation
The Trustees of the University of Pennsylvania
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