Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1995-05-26
1998-08-04
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
4352351, 4353201, 435325, 536 232, C12N 912, C12N 1554, C12N 1585
Patent
active
057892237
ABSTRACT:
This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.
REFERENCES:
Stambolian, et al., "Purification of Human Galactokinase and Evidence For Its Existence as a Monomer Form", (1985), Biochimica Biophysica Acta, 831:306-312.
Lee, et al., "Cloning of a Human Galactokinase Gene (GK2) on Chromosome 15 By Complementation in Yeast", (1992), Proc. Natl. Acad. Sci, USA, 89:10887-10891.
Debouck, et al., "Structure of the Galactokinase Gene of Escherichia coli, the Last (?) Gene of the gal Operon", (1985), Nucl. Acids Research, 13:1841-1853.
Glaser, et al., "Bacillus subtilis Genome Project: Cloning and Sequencing of the 97 kb Region From 325.degree. to 333.degree.", (1993), Molecular Microbiology, 10:371-384.
Houng, et al., "Molecular Cloning and Physical and Functional Characterization of the Salmonella typhimurium and Salmonella typhi Galactose Utilization Operons", (1990), Journal of Bacteriology, 172:4392-4398.
Bergsma Derk Jon
Rosen Craig A.
Ruben Steven M.
Stambolian Dwight Edward
Eagle Alissa M.
King William T.
Lentz Edward T.
Patterson Jr. Charles L.
SmithKline Beecham Corporation
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