Human GAK-related gene variants associated with lung cancer

Details Human GAK-related gene variants associated with lung cancer Human GAK-related gene variants associated with lung cancer

2007-03-06

2007-03-06

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C536S023200, C435S320100, C435S252300, C435S069100

Reexamination Certificate

active

11208877

ABSTRACT:
The invention relates to the nucleic acid and polypeptide sequences of two novel human GAK-related gene variants.The invention also relates to the process for producing the polypeptides of the variants.The invention further relates to the use of the nucleic acid and polypeptide sequences of the gene variants in diagnosing diseases associated with the deficiency of GAK gene, in particular, iron homeostasis impairment-related diseases or non-small cell lung cancer (NSCLC), e.g. large cell lung cancer.

REFERENCES:
Sethi, T. “Science, medicine, and the future: Lung cancer”BMJ, 314 (7081): 652, (1997).
Kanaoka, Y., et al. “GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain”FEBS Letters, vol. 402, p. 73-80, (1997).
Reimer, C.L., et al. “Altered Regulation of Cyclin G in Human Breast Cancer and Its Specific Localization at Replication Foci . . . Cells”J. of Bio. Chem., vol. 274, No. 16, p. 11022-11029, (1999).
Keyomarsi, K., et al. “Redundant cyclin overexpression and gene amplification in breast cancer cells”Proc. Natl. Acad. Sci. USA, vol. 90, p. 1112-1116, (1993).
Horne, M.C., et al. “Cyclin G1 and Cyclin G2 Comprise a New Family of Cyclins with Contrasting Tissue-specific and Cell . . . Expression”J. of Bio. Chem., vol. 271, No. 11, p. 6050-6061, (1996).
Kimura, S.H., et al., “Structure, Expression, and Chromosomal Localization of Human GAK”Genomics, vol. 44, p. 179-187, (1997).
Michelland, S., et al. “Comparison of Chromosomal Imbalances in Neuroendocrine and Non-Small-Cell Lung Carcinomas”Cancer Genet Cytogenet, vol. 114, p. 22-30, (1999).
“On the preparation and utilization of isolated and purified oligonucleotides” [electronic resource], Andrew Chin, allegedly deposited in UNC library on Mar. 14, 2002, date of publication, if any, is in question.

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