Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-04-01
1999-09-07
Spector, Lorraine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 536 231, 536 235, 530300, C07K 14705
Patent
active
059488905
ABSTRACT:
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
REFERENCES:
Buck, et al., Cell 65:175-187 (1991).
Ross, P. C., et al., Proc. Natl. Acad. Sci., 87: 3052-3056 (1990).
Libert F., et al., Science 244: 568-572 (1989).
Eva, C., et al., FEBS Letter 271: 81-84 (1990).
Li Yi
Rosen Craig A.
Ruben Steven M.
Soppet Daniel R.
Brookes A. Anders
Human Genome Sciences Inc.
Lazar-Wesley Eliane
Spector Lorraine
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