Human G-protein receptor HCEGH45

Details Human G-protein receptor HCEGH45 Human G-protein receptor HCEGH45

1995-06-06

1999-02-09

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 435 6, C07H 2102, C07H 2104, C12Q 168

Patent

active

058696326

ABSTRACT:
A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

REFERENCES:
patent: 5328838 (1994-07-01), Galli et al.
patent: 5366889 (1994-11-01), MacDonald et al.
Iismaa et al., Genomics 24(2): 391-394 (1994).
Schweickart et al., Genomics 23: 643-650 (1994).
Heiber et al., DNA and Cell Biology 14(1): 25-35 (1995).
Hata et al., Biochemica et Biophysica ACTA 1261:121-125 (1995).
Marchase et al., Biochemical and Biophysical Research Communications 205(3): 1952-1958(1994).
Marchase et al., Genomics 23: 609-618 (1994).

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