Human G-protein coupled receptor (HIBCD07)

Details Human G-protein coupled receptor (HIBCD07) Human G-protein coupled receptor (HIBCD07)

1998-09-30

2000-08-29

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530324, C07K 14705

Patent

active

061110760

ABSTRACT:
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

REFERENCES:
Nambi Aiyar, et al., "A cDNA Encoding the Calcitonin Gene-related Peptide Type 1 Receptor", The Journal of Biological Chemistry, 271(19):11325-11329 (1996).
GenBank Accession #R61167.
GenBank Accession #H46133.
GenBank Accession #Z44961.
EST #55423.
George et al. "Current Methods in Sequence Comparison and Analysis", Macromolecular Sequencing and Synthesis Selected Methods and Applications, Chapter 12, pp. 127-149 (1988).
Perrin et al. "Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart", Proc. Natl. Acad. Sci., vol. 92, pp. 2969-2973 (1995).

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