Human G-protein coupled receptor (HIBCD07)

Details Human G-protein coupled receptor (HIBCD07) Human G-protein coupled receptor (HIBCD07)

1997-05-07

1999-02-23

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6, 435 71, 435 72, 4352523, 4353201, 536 235, C12N 1512

Patent

active

058742450

ABSTRACT:
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

REFERENCES:
George et al. Macromolecular Sequencing and Synthesis, Selected Methods and Applications. Alan R. Liss, Inc. Chptr 12, pp. 127-149, 1988.
Perrin et al. Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc. Natl. Acad. Sci. 92(7):2969-2973, Mar. 1995.
Nambi Aiyar, et al., "A cDNA Encoding the Calcitonin Gene-related Peptide Type 1 Receptor", The Journal of Biological Chemistry, 271(19):11325-11329 (1996).
GenBank Accession #R61167.
GenBank Accession #H46133.
GenBank Accession #Z44961.
EST #55423.

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