Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-02-27
2007-02-27
O'Hara, Eileen B. (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S387300, C530S402000, C536S023500, C536S023400, C435S069100, C435S069700, C424S001410
Reexamination Certificate
active
10138434
ABSTRACT:
The invention provides a novel, secreted protein that contains a region homologous to ligand binding domain of a cytokine receptor. This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines. Extracellular signaling molecules such as the Wnt family members have essential roles as inducers of cellular proliferation, migration, differentiation, and tissue morphogenesis. As Wnt molecules are known to participate in the aberrant growth associated with neoplasia, Wnt antagonists such as FRP are valuable tools which both for understanding oncogenesis and for the design of new cancer therapies.
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Aaronson Stuart
Finch Paul
He Xi
Rubin Jeffrey S.
Klarquist & Sparkman, LLP
O'Hara Eileen B.
The United States of America as represented by the Department of
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