Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-07
1998-04-28
Walsh, Stephen
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
4241581, 514841, 514843, 530350, A61K 3816, C07K 1472
Patent
active
057444480
ABSTRACT:
The present invention embraces essentially pure human FSH receptor, or a fragment or mutant thereof which binds FSH, DNA encoding said receptor, fragment or mutant, expression vectors comprising said DNA, cells transfected with said expression vectors, and methods of producing said receptor, fragment or mutant by culturing said transfected cells. The present invention also includes pharmaceutical compositions comprising said receptor, fragment or mutant, as well as methods of treating patients with such compositions to reduce endogenous FSH bioactivity. An improved assay for human FSH using the receptor, fragment or mutant of the present invention is also disclosed.
REFERENCES:
patent: 4652450 (1987-03-01), Sluss et al.
patent: 4921808 (1990-05-01), Schneyer et al.
Sprengel, R., et al., Mol. Endocrinol., vol. 4, 525 (1990).
Parmentier, M., et al., Science, vol. 246, 1620 (1989).
Minegish, T., et al., Biochem. Biophys. Res. Comm., vol. 175, 1125 (29 Mar. 1991).
Reichart, L., Jr., et al., "Biochemical Studies on FSH and Its Receptor", Glycoprotein Hormones, W. Chin and I. Boime, eds., (Serono Symposia USA, 1990).
Cheng Shirley Vui Yen
Kelton Christie Ann
Nugent Noreen Patrice
Schweickhardt Rene Lynn
Applied Research Systems ARS Holding N.V.
Spector Lorraine M.
Walsh Stephen
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