Human flavin-containing monooxygenase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

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4352523, 43525233, 43525411, 4353201, 536 232, C12N 902

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active

059424265

ABSTRACT:
A flavin-containing monooxygenase comprising the amino acid sequence of SEQ ID NO:8, a microorganism producing said flavin-containing monooxygenase, a flavin-containing monooxygenase gene containing a DNA sequence coding for the amino acid sequence of SEQ ID NO:8, a flavin-containing monooxygenase gene containing the DNA sequence of SEQ ID NO:7, a plasmid containing said flavin-containing monooxygenase gene, a microorganism containing said plasmid, and a method for producing the enzyme of the present invention wherein said microorganism is cultured to produce the enzyme.

REFERENCES:
Lomari et al. "Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver" Proc. Natl. Acad. Sci. USA. 89, 1685-1689, Mar. 1992.
Dolphin et al., "Differential developmental . . . FMO1, FMO3 and FMO4" Eur. J. Biochem. 235, 683, 1996.
Lawton, Michael P. and Philpot, Richard M., "Functional Characterization of Flavin-containing Monoxygenase 1B1 Expressed in Saccharomyces cervisiae and Escherichia coli and Analysis of Proposed FAD- and Membrane-binding Domains", J. Biol. Chem., 268:8:5728-5734, 1993.
Lawton et al., "A Nomenclature for . . . acid sequence identities", Arch. Biochem. Biophys. 308 (1) pp. 254-257, 1994.
Itoh et al., "Characterization of Recombinant Rat Flavin Containing Mono-Oxygenase (rFMO) Expressed in Yeast and Its Application for Metabolism of Drugs and Toxicants", The 23rd Symp. on Drug-metabolism, Efficacy and Toxicity, pp. 43-46 (English abstract only).
Dolphin et al., "Cloning, Primary Sequence and Chromosomal Localization of Human FMO2, a New Member of the Flavin-Containing Monmo-Oxygenase Family", Biochem. J., 287:261-267, 1992.
Dolphin et al., "Cloning, Primary Sequence, and Chromosomal Mapping of a Human Flavin-Containing Monooxygenase (FMO1)", J.Biol. Chem., 266:19:12379-12385, 1991.
Lomri et al., "Regio- Stereoselective Oxygenations by Adult Human Liver Flavin-Containing Monooxygenase 3. Comparison with Forms 1 and 2", Chem. Res. Toxicol., 6:800-807, 1993.
Burnett et al., "Cloning and Sequences of Flavin-containing Monooxygenases FMO3 and FMO4 from Rabbit and Characterization of FMO3", J. Biol. Chem., 269:14314-14322, 1994.
Lomri et al., "Molecular cloning of flavin-containing Monooxygenase (form II) cDNA from Adult Human Liver", Proc. Natl. Acad. Sci., 92:9910, 1995.
Lomri et al., "Expression in Escherichia coli of the Flavin-Containing Monooxygenase D (Form II) from Adult Human Liver: Determination of a Distinct Tertiary Amine Substrate Specificity", Chem Res. Tox., 6:425-429, 1993.

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