Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-04-04
2006-04-04
Marschel, Ardin H. (Department: 1631)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C702S020000, C536S023100
Reexamination Certificate
active
07022476
ABSTRACT:
The present invention provides methods for predicting the likelihood of development of systemic lupus erythematosus (SLE) in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding FcγRIIB. The invention also provides isolated nucleic acids encoding FcγRIIB polymorphisms, nucleic acid probes that hybridize to polymorphic positions and kits for the prediction of SLE status.
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Mageed, RA, et al., “Immunopathology and the Gene Therapy of Lupus,” Gene Therapy, 2003, vol. 10, pp. 861-874.
Takai, T., “Roles of FcReceptors in Autoimmunity,” Aug. 2002, vol. 2, pp. 580-592.
Jaing, Y., et al., “Genetically Determined Aberrant Down-Regulation of FcγRIIB1 in Germinal Center B Cells Associated With Hyper-IgG and IgG Autoantibodies in Murine Systemic Lupus Erythematosus,” International Immunology, Jun. 1999, vol. 11, No. 10, pp. 1685-1691.
Kyogoku, C., et al., “Fcγ Receptor Gene Polymorphisms in Japanese Patients With Systemic Lupus Erythematosus,” Arthritis & Rheumatsm, May 2002, vol. 46, No. 5, pp. 1242-1254.
Darby & Darby
Marschel Ardin H.
New York Society for Ruptured and Crippled Maintaining the Hospi
Whaley Pablo
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