Human fast-1 gene

Details Human fast-1 gene Human fast-1 gene

1998-07-10

2000-08-29

McKelvey, Terry

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435243, 4353201, 435410, 536 235, C12N 510, C12N 100, C12N 1512, C12N 1563

Patent

active

061107387

ABSTRACT:
hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-.beta. receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-.beta. family. The invention includes tools for investigating the TGF-.beta. signaling pathway and screening for compounds which modulate the action of TGF-.beta..

REFERENCES:
EMBL Database, Heidelberg, FRG Accession number EMEST20:AA218611 Feb. 12, 1997, Hillier, L. Et al. "Zq97H05.rl s NT2 neuronal precursor 937230 Homo sapiens cDNA clone 649977 5'".
Zhou, S. Et al. "Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells" Proceedings of the National Academy of Sciences of USA, vol. 95, No. 5, Mar. 3, 1998.
EMBL Database, Heidelberg, FRG Accession number Emvrt;U70980 Nov. 1, 1996, Rubock, MJ. et al. "Xenopus laevis forkhead activin signal transducer 1 mRNA complete cds".
Chen X et al. "A transcriptional partner for MAD proteins in TGF-beta signatlling" Nature, vol. 383, No. 6602, Oct. 24, 1996, pp. 691-696.
Liu, F. et al. "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes" Genes & Development, vol. 11, No. 23, Dec. 1, 1997 pp. 3157-3167.
Zhou S. et al. "Ahcaracterization of Human Fast-1, a TGFbeta and Activin Signal Transducer" Molecular Cell, vol. 2, No. 1, Jul. 23, 1998, pp. 121-127.
Chen, Genbank Accession U70980--97032727, Jun. 26, 1997.
Clevidence, Genbank Accession L13205--Medline 93248207, Jun. 23, 1993.
Haecker, Genbank Accession M96441--Medline 92409595, May 5, 1993.
Grossniklaus, Genbank Accession X66095 S37037--Medline 92275347, Nov. 22, 1993.
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Celniker, Genbank Accession AC005732, AC004781, AC004329, AC004427, AC003768, AC003769, AC003298, AC003770, AC003299, AC003771, AC003300, AC003772, AC003301, AC003773, AC003302, AC003303, AC003304, AC003305, AC003774, AC003775, A003776, AC004714--Locus AC005732, Oct. 2, 1998.
Ye, Genbank Accession U74613--Medline 97184488, Mar. 6, 1997.
Ye, Genbank Accession U74612--Medline 97184488, Mar. 6, 1997.
Yao, Genbank Accession U83113--Medline 97390411, Oct. 13, 1998.

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