Human erectile dysfunction and methods of treatment

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...

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514 2, 930120, A61K 3900, A61K 3800

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active

059165693

ABSTRACT:
This invention is a method for treating human erectile dysfunction using therapeutic amounts of human growth hormone (GH) administered systemically. Severing the parasympathetic nerves that regulate the erectile function during the course of surgery produces erectile dysfunction. Damage to these nerves by diseases such as diabetes mellitus and alcoholism and during aging may also produce erectile dysfunction. GH stimulates the regeneration of severed parasympathetic nerves that regulate the erectile function restoring potency. GH may act directly or by stimulating the production of insulin-like growth factor-I (IGF-I). The combination of GH plus an IGF (with or without one of the IGF binding proteins) may provide a better response than GH alone.

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Tom F. Lue, M.D. "Physiology of Erection and Pathophysiology of Impotence", Sexual Function,6th Ed., (1992) pp. 709-727.
Skottner, A. et al. "Anabolic and tissue Repair Functions of Recombinant Insulin-Like Growth Factor I", Acta Paediatr Scand, Suppl. 367, (1990) pp. 63-66.
Martin, Human Growth Hormone, Eds. Raiti and Tolman, Plenum Publishing Corporation, NY, NY, pp. 303-323, 1986.
Hintz, Human Growth Hormone, Eds. Raiti and Tolman, Plenum Publishing Corporation, NY, NY, pp. 553-561, 1986.

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