Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-05-12
1992-10-27
Moezie, F. T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530399, 530350, A61K 3736, C07K 1300
Patent
active
051589354
ABSTRACT:
We have now found that one may improve the storage life of EGF without diminishing its biological activity by replacing the Asp at position 11 with a different amino acid, preferably Glu, Asn, Gln, Ala, or Lys, more preferably Glu, or Asn, and most preferably Glu. Other modifications may additionally be made, most preferably by substituting Met.sub.21 (which we have found is susceptible to oxidation) with Ile or a similar amino acid.
REFERENCES:
patent: 4621052 (1986-11-01), Sugimoto
patent: 4628186 (1985-07-01), Nishimura et al.
patent: 4686283 (1987-08-01), Nestor, Jr. et al.
patent: 4717717 (1988-01-01), Finkenaur
patent: 4743679 (1988-05-01), Cohen et al.
patent: 4948875 (1976-04-01), Cohen et al.
Carpenter et al., Ann. Rev. Biochem. (1979) 48:193-216.
Gregory et al., Int. J. Peptide Protein Res. (1977) 9:107-118.
Urdea et al., Proc. Natl. Acad. Sci. (1983) 80:7461-7465.
Oka et al., Proc. Natl. Acad. Sci. (1985) 82:7212-7216.
George-Nascimento et al., Biochem. (1988) 27:797-802.
Makino et al., Proc. Natl. Acad. Sci. (1987) 84:7841-7845.
McFadden et al., Proc. Natl. Acad. Sci. (1987) 84:2595-2599.
Murray et al., J. Bio. Chem. (1984) 259:10722-10732.
Johnson et al., J. Bio. Chem. (1985) 260:10913-10916.
Brake et al., Proc. Natl. Acad. Sci. (1984) 81:4642-4646.
Tom Alber, Annu. Rev. Biochem. 58 765-98 (1989), "Mutational Effects on Protein Stability".
Tom Alber, et al., Nature, 330, 41-46 (1987) "Contributions of Hydrogen Bonds of Thr 157 to The Thermodynamic Stability of phage T.sub.4 Lysozyone".
Medina-Selby Angelica
Nascimento Carlos G.
Chiron Corporation
Moezie F. T.
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