Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2004-09-03
2008-11-18
Saoud, Christine J (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C514S002600, C514S012200, C536S023500, C435S069100
Reexamination Certificate
active
07452970
ABSTRACT:
DNA encoding an endothelin receptor shown in SEQ ID NO: 1 or 2 in the Sequence Listing is isolated from cDNA which is prepared from poly(A)+RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 is an ETA-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 2 is an ETB-receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.
REFERENCES:
patent: 5464853 (1995-11-01), Chan et al.
patent: 5837241 (1998-11-01), Ferrara et al.
patent: 6432994 (2002-08-01), Wu et al.
patent: 6545048 (2003-04-01), Patterson et al.
patent: 6821743 (2004-11-01), Imura et al.
patent: 0 480 381 (1992-04-01), None
Adachi et al. (1991). “Cloning and Characterization of the cDNA Encoding Human A-type Endothelial Receptor,”Biophys. Res. Comm.180(3):1265-1272.
Arai et al. (1990). “Cloning and Expression of a cDNA Encoding an Endothelin Receptor,”Nature348(6303):730-773.
Cyr et al. (1991). “Cloning and Chromosomal Localization of a Human endothelial ETA Receptor,”Biochem. Biophys. Res. Comm.181(1):184-190.
Hosoda et al. (1991). “Cloning and Expressions of Human Endothelial-1 Receptor cDNA,”FEBS Letters287(I, 2):23-26.
Inoue et al. (1989). “The Human Endothelin Family: Three Structurally and Pharmcologically Distinct Isopeptides Predicted by Three Separate Genes,”Proc. Natl. Acad. Sci. USA86(8):2863-2867.
Kloog et al. (1989). “Three Apparent Receptor Subtypes for the Endothelin /Sarafotoxin Family,”FEBS Letters253(1-2):199-202.
Lin et al. (1992). “Cloning and Functional Expression of a Vascular Smooth Muscle Endothelin 1 Receptor,”Chem. Abstracts116(9):165.
Lin, H. Y. et al. (1991). “Cloning and Functional Expression of a Vascular Smooth Muscle Endothelin 1 Receptor,”Proc. Natl. Acad. Sci. USA88(8):3185-3189.
MacCumber et al. (1990). “Endothelin in Brain: Receptors, Mitogenesis, and Biosynthesis in Glial Cells,”Proc. Natl. Acad. Sci USA87(6):2359-2363.
Maggi et al. (1991). “Immunolocalization, Binding, and Biological Activity of Endothelin in Rabbit Uterus: Effect of Ovarian Steroids,”American Journal of Physiology260(2, Pt 1): E292-E305.
Martin et al. (1990). “Heterogenicity of Cell Surface Endothelin Receptors,”Natl. J. Biol. Chem.265(23):14044-14049.
Masu et al. (1987). “cDNA Cloning of Bovine Substance-K Receptor Through Oocyte Expression System,”Nature329(6142):836-838.
Masuda et al. (1989). “Two Different Forms of Endothelin Receptors in Rat Lung,”FEBS Letters257(2):208-210.
Nakamuta et al. (1991). “Cloning and Sequence Analysis of a cDNA Encoding Human Non-Selective Type of Endothelin Receptor,”Biochem. Biophys. Res. Comm.177(1):34-36.
Nakamuta et al. (1992). “Cloning and Sequence Analysis of a cDNA Encoding Human Endothelin Receptor,”Biochem. Biophys. Res. Comm.178(1)248-255.
Ogawa et al. (1991). “Molecular Cloning of a Non-Isopeptide-Selective Human Endothelin Receptor,”Biochem. Biophys. Res. Comm178(1):248-255.
Ogawa et al. (1992). “Molecular Cloning of a Non-Isopeptide Selective Human Endothelin Receptor,”Chem. Abstracts116(13):230.
Sakamoto et al. (1991). “Cloning and Functional Expression of Human cDNA for the ETBEndothelin Receptor,”Biochem. Biophys. Res. Comm.178(2):656-663.
Sakamoto et al. (1992). “Cloning of a cDNA Encoding a Non-Isopeptide-Selective Subtype of the Endothelin Receptor,”Nature348(6303):732-735.
Sakurai et al. (1990). “Cloning of cDNA Encoding a Non-Isopeptide -Selective Subtype of the Endothelin Receptor,”Nature348(6303):732-735.
Shimada et al. (1991). “Endothelin Receptor: a Profoundly Desensitizing Receptor Expressed in Xenopus oocytes,”Eur. J. Pharmacol193(1):123-125.
Simonson et al. (1990). “Cellular Signaling by Peptides of the Endothelin Gene Family,”FASEB Journal4(12):2989-3000.
Wada et al. (1990). “Purification of an Endothelin Receptor from Human Placenta,”Biochem. Biophys. Res. Comm.167(1):251-257.
Watanabe et al. (1989). “Two Distinct Types of Endothelin Receptors are Present on Chick Cardiac Membranes,”Biochem. Biophsys. Res. Comm.161(3):1252-1259.
Wenzel et al. (May 1994). “Endothelin Receptor Antagonists Inhibit Endothelin in Human Skin Microcirculation,”Hypertension23(5):581-586.
Yanagisawa et al. (1988). “A Novel Potent Vasoconstrictor Peptide Produced by Vascular Endothelial Cells,”Nature332:411-415.
Yanagisawa et al. (1989). “Molecular Biology and Biochemistry of the Endothelins,”Trends Pharmacol. Sci10(9):374-378.
Imura Hiroo
Nakanishi Shigetada
Nakao Kazuwa
Lockard Jon M
Morrison & Foerster / LLP
Saoud Christine J
Shionogi Seiyaku Kabushiki Kaisha
LandOfFree
Human endothelin receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human endothelin receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human endothelin receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4022792