Human endothelin-bombesin receptor

Details Human endothelin-bombesin receptor Human endothelin-bombesin receptor

1998-02-26

2000-11-07

Caputa, Anthony

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530350, 530300, 435325, 4353201, 4352523, 43525411, 536 235, 536 231, C12N 1500

Patent

active

061435198

ABSTRACT:
A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

REFERENCES:
Corjay, et al. "Two Distinct Bombesin Receptor Subtypes Are Expressed and Functional in Human Lung Carcinoma Cells," The Journal of Biological Chemistry, vol. 266, No. 28, pp.18771-18779 (1991).
Hosoda, et al. "Targeted and Natural (Piebald-Lethal) Mutations of Endothelin-B Receptor Gene Produce Megacolon Associated with Spotted Coat Color in Mice," Cell, vol. 79, pp. 1267-1276 (1994).
Hori, et al. "Distinct Tissue Distribution and Cellualar Localization of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors," Endocrinology, vol. 130, No. 4, pp. 1885-1895 (1992).
Geneseq Accession No. Q39831 (May-20-1993).
Geneseq Accession No. Q59243 (Mar.-16-1994).
Genbank Accession No. M62108 (May-26-1992).
Adachi et al. (1991) Biochem. & Biophys. Res. Comm. 180(3):1267-1270.
Arai et al. (1990) Nature 348:730-732.
Elshourbagy et al. (1991) Mol. Pharma. 41:465-473.
Hayzer et al. (1992) Amer. J. Med. Sci. 304(4):233-238.
Hosoda et al. (1991) FEBS 287(12):23-26.
Miller et al. (1993) TIPS 14:54-60.
Sakurai et al. (1990) Nature 348:732-735.
Zachary et al. (1987) J. Biol. Chem. 262(9):3947-3950.
Adams et al., Expressed Sequence Tag human gene marker EST00359, Geneseq Accession Number Q39845, Jan. 1993.

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