Human endothelin-3 precursor protein

Details Human endothelin-3 precursor protein Human endothelin-3 precursor protein

1993-12-06

1996-08-20

Walsh, Stephen G.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530326, 930260, C07K 1400, A61K 3816

Patent

active

055480616

ABSTRACT:
Disclosed are (1) a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3, (2) a precursor protein and a mature peptide of endothelin-2 or human endothelin-3, (3) a transformant carrying a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3 and (4) a method for preparing mature endothelin-2 or endothelin-3 which comprises culturing the transformant described in (3), producing and accumulating a protein in a culture medium, and collecting the same. Cells transfected or transformed with the DNA allow large amounts of endothelin-2 or endothelin-3 to be produced, which causes the advantageous production of endothelin-2 or endothelin-3. Endothelin-2 and endothelin-3 can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.

REFERENCES:
Matsumoto et al. (1989) Biochem. Biophys. Res. Comm. 164(1):74-80.
Mills et al. (1992) Biochemistry 31:5640-5645.
Shiba et al. (1992) Biochem. Biophys. Res. Comm. 186(1):588-594.
Ohkubo et al. (1990) Nucleic Acids Res. 18(2):374.
Proceedings of the National Academy of Sciences, vol. 85, pp. 6964-6967 Sep. 1988.
Proceedings of the National Academy of Sciences, vol. 86, pp. 2863-2867 Apr. 1989.
Journal of Biological Chemistry, (Microfilms), vol. 264, No. 30, pp. 18156-18161 (Oct. 25, 1989).
M. Yanagisawa, et al., NATURE, 332:441-445, Mar. 31, 1988.
Y. Itoh, et al., FEBS LETTERS, 321:(2):440-444, Apr. 1988.
M. Yanagisawa, et al., Abstract C-6, 77th Japan Pharmacological Meeting.
I. Kifor, et al., Circulation Research vol. 60, No. 3, 422-428 1987.
K. Hickey, et al., Am. J. Physiol. 248 (Cell Physiol. 17), C550-56 (1985).
R. O'Brien, etal., Journal of Cellular Physiology 132: 263-270 (1987).
M. Gillespie, et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 236, No. 2, 339-343.

Affiliated with

Also associated with

Rating

Human endothelin-3 precursor protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human endothelin-3 precursor protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human endothelin-3 precursor protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2331470