Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2011-06-21
2011-06-21
Lucas, Zachariah (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S007100, C424S184100, C424S185100, C424S186100, C424S187100
Reexamination Certificate
active
07964341
ABSTRACT:
The invention relates to the discovery of a human endogenous retrovirus (HERV) family, Type I HERV-K (HML-2) which appear to be active in vitro and in vivo, infectious, and which have the have the salient features and properties of foamy retroviruses. Based on its natural replication in humans, and that it protects the host from viral and tumor transformation, this non-pathogenic endogenous virus could be developed as a replication competent gene therapy vector. It also is expected to have much higher efficacy than other vectors as it crosses the bloodbrain barrier and infects almost all cell types in the host (proliferating or not). It may naturally lyse tumor cells or infected cells, and thus could even be used without genetic modification. Of course, this vector could be used in traditional ways with it ability to replicate genetically removed. In addition to its value as a vector, as it is reactivated with infection, its detection could also be used to monitor the safety of gene therapy (irrespective of vector type used), as well as other biological therapies including vaccination, blood transfusion, transplantation and xenotransplantation. Finally it may be used to screen for new therapeutic and prophylactic treatments for a wide variety of diseases.
REFERENCES:
Löwer et al. Identifi'cation of human endogenous retroviruses with complex mRNA expression and particle formation. Proceedings of the National Academy of Sciences of the United States of America 1993, vol. 90, pp. 4480-4484.
Kleiman et al. HERV-K(HML-2) GAG/ENV Antibodies as Indicator for Therapy Effect in Patients With Germ Cell Tumors. Internal Journal of Cancer 2004, vol. 110, pp. 459-461.
Tonjes RR et al Genome-wide screening, cloning, chromosomal assignment, and expression of full length human endogenous retrovirus type K: Journal of Virology, Nov. 1999 vol. 73, No. 11 pp. 9187-9195.
Kuhelj R. et al “Inhibition of human endogenous retrovirus K10 protease in cell free and cell based assays” The Journal of Biological Chemistry May 2001, vol. 276 No. 20 pp. 16674-16682.
Etkind PR et al “type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D” Virology Aug. 1997 vol. 234 No. 2 pp. 304-308.
Patience C et al “Human endogenous retroviral expression and reverse transcriptase activity in the T47D mammary carcinoma cell line” Journal of Virology Apr. 1996 vol. 70 No. 4 pp. 2654-2657.
Conejero-Goldberg C et al—“infectious pathogen detection arrays: viral detection in cell lines and postmortem brain tissue” Biotechniques Nov. 2005, vol. 39 No. 5 pp. 741-749.
Frank O et al—Human Endogenous retrovirus expression profiles in samples from brains of patients with schizophrinia and bipolar disorders Journal of Virology Sep. 2005 vol. 79 No. 17 pp. 10890-10901.
Ejthadi HD et al A novel multiplex RT-PCR system detects human endogenous retrovirus K in breast cancer Archives of Virology Jan. 2005 vol. 150 No. 1 pp. 177-184.
Morgan D et al “Human endogenous retrovirus (HERV-K) particles in megakaryocytes cultured from essential thrombocythemia peripheral blood stem cells” Experimental Hemtology Jun. 2004 vol. 32 No. 6 pp. 520-525.
Wang-Johanning F et al “Expression of human endogenous retrovirus K Envelope transcripts in human breast cancer” Clinical Cancer Research Jun. 2001 vol. 7 No. 6 pp. 1553-1560.
Barbulescu M et al “Many human retrovirus K (HERV-K) proviruses are unique to humans” Current Biology Aug. 1999 vol. 9 pp. 861-868.
Ono M. et al Nucleotide sequence of human endogenous retrovirus genome related to teh mouse mammary tumor virus genome Journal of Virology Nov. 1986 vol. 60 No. 2 pp. 589-598.
Diaz-Mitoma Francisco
Giulivi Antonio
Laderoute Marian
Larocque Louise
Humphrey Louise
Lucas Zachariah
Williams Michael R.
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