Human Emr1-like G protein coupled receptor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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536 231, 536 2431, 4353201, 435325, 4352523, 4351723, C07H 2104, C12N 1502, C12N 1563

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active

060134798

ABSTRACT:
The invention provides a human Emr1-like G protein coupled receptor (EGPCR) and polynucleotides which identify and encode EGPCR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of EGPCR.

REFERENCES:
PROSITE: PS00237.
Watson, S. And Arkinstall, S., The G-Protein Linked Receptor FactsBook, Academic Press, San Diego, CA, pp. 2-6 (1994).
Baud, V., et al., "EMR1, an Unusual Member in the Family of Hormone Receptors with Seven Transmembrane Segments," Genomics, 26:334-344 (1995) (GI 784993).
Gray, JX, et al., "CD97 is a Processed, Seven-Transmembrane, Heterodimeric Receptor Associated with Inflammation,," Journal of Immunology, 157(12):5438-5447 (1996).
Baud, V., et al., (GI 784993) GenBank Sequence Database (Accession X81479), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Lamerdin, J.E., et al. (GI 2935596) GenBank Sequence Database (Accession AC004262), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Bolton, A.E. and Hunter, W.M., "The Labelling of Proteins to High Specific Radioactivities by Conjugation to a .sup.125 I-Containing Acylating Agent," Biochem. J., 133:529-539 (1973).

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