Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1994-07-05
1998-01-20
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4351723, 4352401, 4352523, 43525411, 4353201, 435 691, 536 232, C12N 118, C12N 120, C12N 510, C12N 966, C12N 1557, C12N 1563
Patent
active
057100357
ABSTRACT:
Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration.
REFERENCES:
patent: 4968614 (1990-11-01), Takiguchi et al.
patent: 4985361 (1991-01-01), Takiguchi et al.
Bowie et al. (1990) Science 247: 1306-1310.
Kang, J. et al., Identification of cDNAs encoding two novel rat pancreatic serine proteases, Gene, 11:181-7 (1992).
Adams Mark D.
Greene John M.
Bugaisky G. E.
Ferraro Gregory D.
Human Genome Sciences Inc.
Olstein Elliot M.
Wax Robert A.
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