Human E3α ubiquitin ligase family

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

Reexamination Certificate

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C435S007100, C530S387100, C536S023200

Reexamination Certificate

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10758672

ABSTRACT:
The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for these and related products.

REFERENCES:
patent: 5861312 (1999-01-01), Varshavsky et al.
patent: 6706505 (2004-03-01), Han et al.
patent: WO 98/23283 (1998-06-01), None
Baracos et al., “Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachetic rats bearing a hepatoma”,Am J Physiol268 (Endocrinol Metab):E996-1006, 1995.
Bartel et al., “The recognition component of the N-end rule pathway”EMBO J9:3179-3189, 1990.
Ciechanover, “The ubiquitin-proteasome pathway: on protein death and cell life”,EMBO J17:7151-7160, 1998.
Hillier et al., Database GenBank. Accession No. AI929033, Aug. 23, 1999.
Kwon et al., “The mouse and human genes encoding the recognition component of the N-end rule pathway”,Proc Natl Acad Sci. USA95:7898-7903, 1998.
Lecker et al., “Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states”,J Nutr129:227S-237S, 1999.
Matsumoto et al., “Tumor inoculation site-dependent induction of cachexia in mice bearing colon 26 carcinoma”,Brit J Cancer79:764-769, 1999.
Mitch et al., “Mechanisms of muscle wasting: the role of ubiquitin-proteasome pathway”,New England J Med335:1897-1905, 1996.
Reiss et al., “Affinity purification of ubiquitin-protein ligase on immobilized protein substrates”,J Biol Chem265:3685-3690, 1990.
Solomon et al., “Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway”,Proc Natl Acad Sci USA95:12602-12607, 1998.
Strausberg et al. Database GenBank. Accession No. AI361043, Feb. 15, 1999.
Tanaka et al., “Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice”,Cancer Res50: 2290-2295, 1990.
Wilson et al., “2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans”,Nature368:32-38, 1994.
Database GenBank. National Library of Medicine, (Bethesda, Maryland, US), Accession No. U88308, The C. elegans Sequencing Consortium, “Genome sequence of the nematode C. elegans: a platform for investigating biology: the C. elegans sequencing consortium”, Science 282:2012-2018, 1998.
Database GenBank. National Library of Medicine, (Bethesda, Maryland, US), Accession No. AF061555, Kwon et al., “The mouse and human genes encoding the recognition component of the N-end rule pathway”, Proc Natl Acad Sci, USA 95:7898-7903, 1998.
Database GenBank. National Library of Medicine, (Bethesda, Maryland, US), Accession No. AI187306, Strausberg, qf28h08.x1 Soares—testis—NHTHomo sapienscDNA clone IMAGE:1751391 3′, mRNA sequence; National Cancer Institute, Cancer Genome Anatomy Project, 1997.
Database GenBank. National Library of Medicine, (Bethesda, Maryland, US), Accession No. AI192195, Strausberg, qc92e08.x1 Soares—pregnant—uterus—NbHPU Homo sapiens cDNA clone IMAGE:1721702 3′ similar to TR:O15057 O15057 KIAA0349; mRNA sequence; National Cancer Institute, Cancer Genome Anatomy Project, 1997.
Database GenBank. National Library of Medicine, (Bethesda, Maryland, US), Accession No. AI400279, Strausberg, tg43b12.x1 Soares—NFL—T—GBC—S1Homo sapienscDNA clone IMAGE:2111519 3′, mRNA sequence; National Cancer Institute, Cancer Genome Anatomy Project, 1997.
Database GenBank. National Library of Medicine, (Bethesda, Maryland, US), Accession No. AA002347, Marra et al., mg53g07.r1 Soares mouse embryo NbME13.5 14.5Mus musculuscDNA clone IMAGE:427548 5′ similar to gb:U24428Mus musculusmu-class glutathione s-transferase (MOUSE); mRNA sequence, The WashU-HHMI Mouse EST Project, 1996.

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