Human E3 ubiquitin protein ligase

Details Human E3 ubiquitin protein ligase Human E3 ubiquitin protein ligase

1998-04-30

1999-11-02

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435243, 4352542, 4353201, 435325, 435410, 435455, 536 231, 536 232, 536 243, 536 2431, 536 2433, C12N 900, C12N 1552, C12N 1511, C07H 2104

Patent

active

059768495

ABSTRACT:
A novel human E3 ubiquitin protein ligase is provided as well as a nucleic acid structural region which encodes the polypeptide and the amino acid residue sequence of the human biomolecule. Methods are provided to identify compounds that modulate the biological activity of the molecule and hence regulate cellular and tissue physiology.

REFERENCES:
Hochstrasser, Mark; Ubiquitin-Dependent Protein Degragation, Annu. Rev. Genet. 1996, 30:405-39.
Weissman, Alan M.; Regulating Degradation by Ubiquitination, Review Immunology Today, vol. 18, No. 4 189, Apr. 1997.
Pahl, Heike L. et al.; Control of Gene Expression by Proteolysis, Current Opinion in Cell Biology 1996, 8:340-347.
Rolfe, Mark et al.; The Ubiquitin-Mediated Proteolytic Pathway as a Therapeutic Area, J. Mol. Med. (1997) 75:5-17.
Perry, William L. et al.; The Itchy Locus Encodes a Novel Ubiquitin Protein Ligase That is Disrupted in a .sup.18h Mice, Nature Genetics, vol. 18, Feb. 1998.
D'Andrea, Alan D., Relieving the Itch, Nature Genetics, vol. 18, Feb. 1998.

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