Human DNase I hyperactive variants

Details Human DNase I hyperactive variants Human DNase I hyperactive variants

2004-05-03

2008-08-05

Ramirez, Delia M (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S019000, C435S069100, C435S320100, C435S252300, C435S325000, C435S004000, C435S006120, C435S183000, C435S195000, C536S023200, C530S350000, C424S094600

Reexamination Certificate

active

07407785

ABSTRACT:
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of hyperactive-variants of human DNase I.

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