Human DNA topoisomerase I .alpha.

Details Human DNA topoisomerase I .alpha. Human DNA topoisomerase I .alpha.

1995-06-02

1998-03-03

Ketter, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 435233, 4353201, 536 232, 536 235, C12P 2102, C12N 1512, C12N 990

Patent

active

057233110

ABSTRACT:
Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

REFERENCES:
Wetmore et al. Human lung expresses unique gamma-glutamyl transpeptidase transcripts Proc. Natl. Acad. Sci. U.S.A. vol. 90 7461-7465, 1993.
Voojis et al. Libraries for each human chromosome, constructed from sorter-enriched chromosomes by using linker-adaptor PCR Am. J. Human Genetics vol. 52 586-597, 1993.

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