Human DNA topoisomerase I .alpha.

Details Human DNA topoisomerase I .alpha. Human DNA topoisomerase I .alpha.

1998-03-02

1999-10-19

Brusca, John S.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Isomerase

530350, C12N 990, C07K 14435

Patent

active

059688033

ABSTRACT:
Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

REFERENCES:
patent: 5070192 (1991-12-01), Earnshaw et al.
Genbank Accession No. T07355 (Sequence and Annotations only).
Wetmore, L.A. et al. (1993) Proc. Natl. Acad. Sci. 90:7461-7465.
Vooijs, M. et al. (1993) Am. J. Human Genet. 52:586-597.
Chemical Abstracts vol. 121 Abstract 1026227g.
Madden, K.R. et al. (1992) Cancer Research 52(1):525-532.
D'Arpa, P. et al. (1988) Proc. Natl. Acad. Sci. 85:2543-2547.

Affiliated with

Also associated with

Rating

Human DNA topoisomerase I .alpha. does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human DNA topoisomerase I .alpha., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human DNA topoisomerase I .alpha. will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2054844