Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-06-06
2006-06-06
Romeo, David (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S300000, C530S324000, C530S866000
Reexamination Certificate
active
07057017
ABSTRACT:
Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
REFERENCES:
patent: 5168050 (1992-12-01), Hammonds, Jr. et al.
patent: 5525486 (1996-06-01), Honjo et al.
patent: 6844422 (2005-01-01), Niehrs et al.
patent: 2005/0069915 (2005-03-01), McCarthy
patent: 2005/0079173 (2005-04-01), Niehrs et al.
patent: WO 98/27932 (1998-07-01), None
patent: WO 98/46755 (1998-10-01), None
patent: WO 99/14328 (1999-01-01), None
patent: WO 99/06549 (1999-02-01), None
patent: WO 99/03990 (1999-03-01), None
patent: WO 99/22000 (1999-05-01), None
patent: WO 99/31236 (1999-06-01), None
patent: WO 99/46281 (1999-09-01), None
patent: WO 00/12708 (2000-03-01), None
patent: WO 00/18194 (2000-03-01), None
patent: WO 00/18914 (2000-04-01), None
patent: WO 00/53756 (2000-09-01), None
patent: WO 00/78961 (2000-12-01), None
patent: WO 01/04311 (2001-01-01), None
patent: WO 01/16318 (2001-03-01), None
patent: WO 01/38528 (2001-05-01), None
patent: WO 01/40466 (2001-06-01), None
patent: WO 01/54477 (2001-08-01), None
patent: WO 01/57188 (2001-08-01), None
patent: WO 01/57190 (2001-08-01), None
patent: WO 01/68848 (2001-09-01), None
Aravind, L. and E.V. Koonin, “A colipase fold in the carboxy-terminal domain of the Wnt antagonists—the Dickkopfs”,Curr. Biol. 8(14):R477-8 (1998).
Austin, T.W. et al., “A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells”,Blood89(10):3624-3635 (1997).
Barton, “Protein sequence alignment and database scanning” inProtein Structure Prediction, A Practical Approach(IRL Press, Oxford University Press, Oxford, UK, Jan. 1997) pp. 31-63.
Bowie et al. “Deciphering the message in protein sequences: tolerance to amino acid substitutions”Science247(4948):1306-10 (Mar. 16, 1990).
Cadigan, K.M et al., “Wnt signaling: A common theme in animal development”,Genes&Development11:3286-3305 (1997).
Fedi, P. et al., “Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling”,J. Biol. Chem. 274(27):19465-19472 (1999).
Finch, Paul W. et al. “Purification and molecular cloning of a screted, Frizzled-related antagonist of Wnt action”Proc. Natl. Acad. Sci. USA94(13):6770-75 (Jun. 1997).
GenBank™ Accession No. 2724106 for RIG-like 7-1 [Homo sapiens][Dec. 4, 1997].
GenBank™ Accession No. 2736292 for mdkkk-1 [Mus musculus][Feb. 10, 1998].
GenBank™ Accession No. 2736294 for Xdkk-1 [Xenopus laevis][Feb. 10, 1999].
GenBank™ Accession No. 3660556 for hdkk-4 [Homo sapiens][Oct. 3, 1998].
GenBank™ Accession No. 3688630 for hdkk-4 [Homo sapiens][Oct. 3, 1998].
GenBank™ Accession No. A39976 for Sequence 9 from Patent WO942179 [Mar. 5, 1997].
GenBank™ Accession No. AA018255 for Soares retina N2b4HRHomo sapienscDNA clone 361535 5′, mRNA sequence [Nov. 29, 1996].
GenBank™ Accession No. AA031969 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone 470646 3′, mRNA sequence [Aug. 21, 1996].
GenBank™ Accession No. AA032060 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:470646 5′, mRNA sequence [Aug. 21, 1996].
GenBank™ Accession No. AA035345 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:471479 3′, mRNA sequence [May 10, 1997].
GenBank™ Accession No. AA035443 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE;471724 3′, mRNA sequence [May 10, 1997].
GenBank™ Accession No. AA035583 for Soares—pregnant—uterus—NbHPUHomo sapiensclone IMAGE:471724 5′, mRNA sequence [May 10, 1997].
GenBank™ Accession No. AA037322 for Soares—senescent—fibroblasts—NbHSFHomo sapienscCNA clone 325915 5′, mRNA sequence [Nov. 25, 1996].
GenBank™ Accession No. AA041360 for Soares—fetal—heart—NbHH19WHomo sapienscDNA clone 376472 3′, mRNA sequence [Feb. 1, 1997].
GenBank™ Accession No. AA042806 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:486515 3′, mRNA sequence [Sep. 4, 1996].
GenBank™ Accession No. AA043027 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:486515 5′, mRNA sequence [Sep. 4, 1996].
GenBank™ Accession No. AA063859 for Stratagene mouse testis (#937309)Mus musculuscDNA clone 514640 5′ similar to TR:G517093 G517093 Hypothetical 39.2 KD Protein; mRNA sequence [Feb. 3, 1997].
GenBank™ Accession No. AA065307 for Testis 5Homo sapienscDNA clone a03500 5′ end, mRNA sequence [Dec. 31, 1996].
GenBank™ Accession No. AA073904 for Stratagene mouse heart (#937316)Mus musculuscDNA clone 536577 5′, mRNA sequence [Feb. 15, 1997].
GenBank™ Accession No. AA88618 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:487642 5′, mRNA sequence [Oct. 24, 1996].
GenBank™ Accession No. AA107210 for Stratagene mouse testic (#937308)Mus musculuscDNA clone IMAGE:516168 5′ similar to TR:G517093 G517093 HYPOTHETICAL 39.2 kd protein; mRNA sequence [Feb. 3, 1997].
GenBank™ Accession No. AA115249 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:501425 3′, mRNA sequence [May. 14, 1997].
GenBank™ Accession No. AA115337 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone 501425 5′, mRNA sequence [May 14, 1997].
GenBank™ Accession No. AA129488 for Stratagene lung carcinoma 937218Homo sapienscDNA clone IMAGE:564360 3′, mRNA sequence [May 19, 1997].
GenBank™ Accession No. AA136192 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:490113 5′, mRNA sequence [Nov. 30, 1996].
GenBank™ Accession No. AA137219 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:490113 3′, mRNA sequence [Nov. 30, 1996].
GenBank™ Accession No. AA143670 for Stratagaene pancreas (#937208)Homo sapienscDNA clone IMAGE:591770 5′, mRNA sequence [Dec. 4, 1996].
GenBank™ Accession No. AA155928 for Stratagene endothelial cell 937223Homo sapienscDNA clone 590026 5′, mRNA sequence [Dec. 11, 1996].
GenBank™ Accession No. AA207078 for NCI—CGAP—GCB1Homo sapienscDNA clone IMAGE:682716 5′, mRNA sequence [Aug. 13, 1997].
GenBank™ Accession No. AA209468 for Stratagene hNT neuron (#937233)Homo sapienscDNA clone 648310 3′, mRNA sequence [Mar. 12, 1998].
GenBank™ Accession No. AA220766 for Soares mouse 3NME 12 5Mus musculuscDNA clone IMAGE:660068 5′, mRNA sequence [Feb. 10, 1997].
GenBank™ Accession No. AA237194 for Soares mouse NMLMus musculuscDNA clone IMAGE:678567 5′ similar to gb:U11248Mus musculusC57BL/6J ribosomal protein S28 mRNA, complete (MOUSE), mRNA sequence [Mar. 3, 1997].
GenBank™ Accession No. AA253446 for Soares—NhHMPu—S1Homo sapienscDNA clone IMAGE:669375 5′, mRNA sequence [Mar. 12, 1997].
GenBank™ Accession No. AA253464 for Soares—NhHMPu—S1Homo sapienscDNA clone 669375 3′, mRNA sequence [Mar. 12, 1997].
GenBank™ Accession No. AA259742 for Soares mouse 3NME 12 5Mus musculuscDNA clone IMAGE:734543 5′ similar to gb:U
Ausenhus Scott L.
Cloutier Mario
Millennium Pharmaceuticals Inc.
Romeo David
Underwood Robert H.
LandOfFree
Human dickkopf-related protein and nucleic acid molecules... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human dickkopf-related protein and nucleic acid molecules..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human dickkopf-related protein and nucleic acid molecules... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3660215