Human Dickkopf-related nucleic acid molecules

Details Human Dickkopf-related nucleic acid molecules Human Dickkopf-related nucleic acid molecules

2005-10-21

2009-08-25

Romeo, David S (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252300, C435S254200, C435S320100, C435S325000, C435S348000, C530S350000, C536S023400, C536S023500, C536S024100

Reexamination Certificate

active

07579168

ABSTRACT:
Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 5168050 (1992-12-01), Hammonds, Jr. et al.
patent: 5525486 (1996-06-01), Honjo et al.
patent: 6844422 (2005-01-01), Niehrs et al.
patent: 2003/0068312 (2003-04-01), McCarthy
patent: 2004/0234515 (2004-11-01), McCarthy
patent: 2005/0069915 (2005-03-01), McCarthy
patent: 2005/0079173 (2005-04-01), Niehrs et al.
patent: 2007/0077244 (2007-04-01), Niehrs et al.
patent: 197 47 418.7 (1998-11-01), None
patent: WO 98/27932 (1998-07-01), None
patent: WO 98/46755 (1998-10-01), None
patent: WO 99/03990 (1999-01-01), None
patent: WO 99/06549 (1999-02-01), None
patent: WO 99/14328 (1999-03-01), None
patent: WO 99/22000 (1999-05-01), None
patent: WO 99/31236 (1999-06-01), None
patent: WO 99/46281 (1999-09-01), None
patent: WO 00/12708 (2000-03-01), None
patent: WO 00/18194 (2000-03-01), None
patent: WO 00/18914 (2000-04-01), None
patent: WO 00/53756 (2000-09-01), None
patent: WO 00/78961 (2000-12-01), None
patent: WO 01/04311 (2001-01-01), None
patent: WO 01/16318 (2001-03-01), None
patent: WO 01/38528 (2001-05-01), None
patent: WO 01/40466 (2001-06-01), None
patent: WO 01/54477 (2001-08-01), None
patent: WO 01/57188 (2001-08-01), None
patent: WO 01/57190 (2001-08-01), None
patent: WO 01/68848 (2001-09-01), None
T. Pawson. 1995. Protein modules and signalling networks. Nature 373: 573-580.
Biochemistry [online]. 5th edition. W. H. Freeman and Company, 2002 [retrieved Dec. 30, 2007]. Retrieved from the Internet:<http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=stryer.section.2117> II. Transducing and Storing Energy 15. Signal-Transduction Pathways: An Introduction to Information Metabolism, Summary.
Rubin et al. Secreted WNT antagonists as tumor suppressors: pro and con. Front Biosci. Sep. 1, 2006;11:2093-105.
U.S. Appl. No. 09/009,802, filed Jan. 20, 1998, McCarthy, Sean A.
U.S. Appl. No. 11/069,137, filed Feb. 28, 2005, McCarthy, Sean A.
Aravind, L. and Koonin, E.V., “A colipase fold in the carboxy-terminal domain of the Wnt antagonists-the Dickkopfs,”Curr. Biol., 8(14):R477-8 (1998).
Austin, T.W. et al., “A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells,” Blood 89(10):3624-3635 (1997).
Barton, “Protein sequence alignment and database scanning,” inProtein Structure Predicition, A Practical Approach(IRL Press, Oxford University Press, Oxford, UK, pp. 31-63 (Jan. 1997).
Bowie et al., “Deciphering the message in protein sequences: tolerance to amino acid substitutions,”Science, 247(4948):1306-1310 1990).
Cadigan, K.M. et al., “Wnt signaling: A common theme in animal development,”Genes&Development, 11:3286-3305 (1997).
Daniel, C. et al., “Mapping of linear antigenic sites on the S glycoprotein of a neurotropic murine coronavirus with synthetic peptides: A combination of nine prediction algorithms fails to identify relevant epitopes and peptide immunogenicity is drastically influenced by the nature of the protein carrier,”Virology, 202: 540-549, 1994.
Fedi, P. et al., “Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling,”J. Biol. Chem., 274(27):19465-19472 (1999).
Finch, P.W. et al., “Purification and molecular cloning of a secreted, Fizzled-related antagonist of Wnt action,”Proc. Natl. Acad. Sci. USA, 94(13):6770-6775 (1997).
GenBank™ Accession No. 2724106 for RIG-like 7-1 [Homo sapiens] (1997).
GenBank™ Accession No. 2736292 for mdkk-1 [Mus musculus] (1998).
GenBank™ Accession No. 2736294 for Xdkk-1 [Xenopus laevis] (1998).
GenBank™ Accession No. 3660556 for hdkk-4 [Homo sapiens] (1998).
GenBank™ Accession No. 3688630 for hdkk-4 [Homo sapiens] (1998).
GenBank™ Accession No. A39976 for Sequence 9 from Patent WO942179 (1997).
GenBank™ Accession No. AA031969 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone 470646 3′, mRNA sequence (1996).
GenBank™ Accession No. AA032060 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone Image:470646 5′, mRNA sequence (Aug. 21, 1996).
GenBank™ Accession No. AA035345 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone Image:471479 3′, mRNA sequence (1997).
GenBank™ Accession No. AA035443 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone Image:471724 3′, mRNA sequence (1997).
GenBank™ Accession No. AA035583 for Soares—pregnant—uterus—NbHPUHomo sapiensclone Image:471724 5′, mRNA sequence (1997).
GenBank™ Accession No. AA037322 for Soares—senescent—fibroblasts—NbHSFHomo sapienscDNA clone 325915 5′, mRNA sequence (1996).
GenBank™ Accession No. 3688630 for hdkk-4 [Homo sapiens] (1998).
GenBank™ Accession No. A39976 for Sequence 9 from Patent WO942179 (1997).
GenBank™ Accession No. AA 018255 for Soares retina N2b4HRHomo sapienscDNA clone 361535 5′, mRNA sequence (1996).
GenBank™ Accession No. AA031969 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone 470646 3′, mRNA sequence (1996).
GenBank™ Accession No. AA032060 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone Image:470646 5′, mRNA sequence (Aug. 21, 1996).
GenBank™ Accession No. AA035443 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone Image:471724 3′, mRNA sequence (1997).
GenBank™ Accession No. AA035583 for Soares—pregnant—uterus—NbHPUHomo sapiensclone Image:471724 5′, mRNA sequence (1997).
GenBank™ Accession No. AA037322 for Soares—senescent—fibroblasts—NbHSFHomo sapienscDNA clone 325915 5′, mRNA sequence (1996).
GenBank™ Accession No. AA041360 for Soares—fetal—heart—NbHH19WHomo sapienscDNA clone 376472 3′, mRNA sequence (1997).
GenBank™ Accession No. AA042806 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone Image:486515 3′, mRNA sequence (1996).
GenBank™ Accession No. AA043027 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone Image:486515 5′, mRNA sequence (1996).
GenBank™ Accession No. AA063859 for Stratagene mouse testis (#937309)Mus musculuscDNA clone 514640 5′ similar to TR:G517093 G517093 Hypothetical 39.2 KD Protein; mRNA sequence (1997).
GenBank™ Accession No. AA065307 for Testis 5Homo sapienscDNA clone a03500 5′ end, mRNA sequence (1996).
GenBank™ Accession No. AA073904 for Stratagene mouse heart (#937316)Mus musculuscDNA clone 53677 5′, mRNA sequence (1997).
GenBank™ Accession No. AA088618 for Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone Image:487642 5′, mRNA sequence (1996).
GenBank™ Accession No. AA107210 for Stratagene mouse testic (#937308)Mus musculuscDNA clone Image:516168 5′ similar to TR:G517093 G517093 Hypothetical 39.2 kd protein; mRNA sequence (1997).
GenBank™ Accession No. AA115249 for Soares—pregnant-uterus-NbHPUHomo sapienscDNA clone Image:501425 3′, mRNA sequence (1997).
GenBank™ Accession No. AA115337 for Soares—pregnant—uterus—NbHPU

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