Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-07-17
1999-02-16
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 435 6, 435 912, 536 231, 536 235, 536 2433, C12N 1500
Patent
active
058719717
ABSTRACT:
The invention provides a human human developmentally regulated GTP-binding protein (HDRG) and polynucleotides which identify and encode HDRG. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HDRG.
REFERENCES:
Alberts, B. et al., Molecular Biology of the Cell, Garland Publishing, Inc., New York, NY, pp. 85, 206-209, 211, 239-240, 641-645 (1994).
Bourne, H., "GTPases: a family of molecular switches and clocks", Philos. Trans. R. Soc. Lond. B., 349:283-289 (1995).
Mori, T. et al., "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6", Cytogenet. Cell Genet., 73:224-227 (1996).
Sazuka, T. et al., "Expression of DRG During Murine Embryonic Development", Biochem. Biophys., Res. Comm., 189:371-377 (1992).
Kumar, S. et al., "Expression of GTP-binding protein gene drg during Xenopus laevis development", Int. J. Dev. Biol., 37:539-546 (1993).
Sommer, K.A. et al., "The gene upstream of DmRP128 codes for a novel GTP-binding protein of Drossophila melanogaster", Mol. Gen. Genet., 242:391-398 (1994) (GI 311342; GI 311343).
Sazuka, T. et al.; "DRG: A Novel Developmentally Regulated GTP-Binding Protein", Biochem. Biophys. Res. Comm., 189:363-370 (1992) (GI 220506; GI 220507).
Meij, Johanna T.A., "Regulation of G protein function: Implications for heart disease", Mol. Cell. Biochem., 157:31-38 (1996).
Olson, M.F., "Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?", J. Mol. Med., 74:563-571 (1996).
Wilson, C. et al., "Integration of Membrane Proteins into the Endoplasmic Reticulum Requires GTP", J. Cell. Biol., 107:69-77 (1988).
Sazuka, T. et al., (Direct Submission), GenBank Sequence Database (Accession D10715), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 220506; GI 220507).
Sommer, K.A. et al., (Direct Submission), GenBank Sequence Database (Accession X71866), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 311342; GI 311343).
Sazuka et al. (1992) Biochem. Biophys. Res. Comm. 189:363-70.
Sazuka et al. (1992) Biochem. Biophys. Res. Comm. 189:371-377.
Sazuka et al. (1992) GenBank Database, Accession No. P32233.
Sazuka et al. (1992) GenBank Database, Accession No. D10715.
Corley Neil C.
Hillman Jennifer L.
Lal Preeti
Shah Purvi
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Longton Enrique D.
Mohan-Peterson Sheela
Wax Robert A.
LandOfFree
Human developmentally regulated GTP-binding protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human developmentally regulated GTP-binding protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human developmentally regulated GTP-binding protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2061402