Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2007-02-20
2007-02-20
Ramirez, Delia M. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S023000, C435S069100, C435S320100, C435S252300, C435S325000, C530S350000, C536S023200, C536S023500
Reexamination Certificate
active
10379981
ABSTRACT:
Human and murine analogs of DUBs, hematopoietic-specific, cytokine-inducible deubiquitinating proteases, clustered on chromosome 7 and and their respective regulatory regions are identified. The nucleotide or proteins encoded thereby may be used in assays to identify inhibitors of hDUB7, human deubiquitinating enzyme, or mDUB7, mouse deubiquitinating enzyme. The invention also includes transducing peptides comprising an NLS, nuclear localization signal, or transducing sequence of hDUB7 or mDUB7 linked to a cargo molecule, and methods of delivering a biologically active protein, therapeutically effective compound, antisense nucleotide, or test compound to a cell wherein a transducing peptide is added exogenously to a cell.
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Hahn Chang S.
Liu Hong
Aventis Pharmaceuticals Inc.
Jones George S.
Ramirez Delia M.
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