Human desaturase gene and uses thereof

Details Human desaturase gene and uses thereof Human desaturase gene and uses thereof

2005-02-22

2005-02-22

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S252300, C435S320100, C435S136000, C536S023200, C530S350000

Reexamination Certificate

active

06858416

ABSTRACT:
The subject invention relates to the identification of a gene involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “human Δ5-desaturase”) and to uses thereof. In particular, human Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

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Sequence search alignments for Applicants SEQ ID Nos. 1 & 12 and Accession Nos. AAV63643 & AAW85135 as per WO9846765-A1 (Chaudhary et al., Oct. 22, 1998).*
Lamerdin, J.E., et al. “BC269730_2”, EMBL DAtabase Entry 060427; Accession No. 060427.
Cho, H.P., et al., “Cloning, Expression, and Fatty Acid Regulation of the Human Delta-5 Desaturase,” Journal of Biological Chemistry, vol. 273, No. 30, pp. 37335-37339, XP002140847 (Dec. 24, 1999).
Michaelson, L., et al., “Isolation of Delta5-Fatty Acid Desaturase Gene fromMortierella Alplina,” Journal of Biolgoical Chemestry, vol. 273, No. 30, pp. 19055-19059, (Jul., 1998).
“The Faseb Journal,” Abstracts, part I, Abstract 3093, p. A532 (Experimental Biology 98, San Francisco, CA, Apr. 18-22, 1998).
Knutzon, D.S., et al, “Identification of 5-Desaturase fromMortierella Alpinaby Heterologous Expression in Bakers' Yeast and Canola,” The Journal of Biological Chemistry, vol., 23, No. 45, pp. 29360-29366 (Nov. 6, 1998).
Cho, H.P., et al., “Cloning, Expression, and Nutritional Regulation of the Mammalian-6 Desaturase,” The Journal of Biological Chemistry, vol. 274, No. 1, pp. 471-477 (Jan. 1, 1999).
Lamerdin, J.E., et al., “Sequence Analysis of a Human BAC Containing the FEN1 DNA Repair Gene,”, Accession AC004770, (Jun. 12, 1998), GenBank.
Sequence Search Alignment of Applicants' SEQ ID No.: 1 and DNA Sequence published in Chaudhury, et al., (WO9846763-A1, Oct. 22, 1998).

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