Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-08-08
2006-08-08
Andres, Janet (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000, C530S350000
Reexamination Certificate
active
07087406
ABSTRACT:
A human-derived bradeion protein, which has the following properties: (i) it is a transmembranous protein; (ii) it has a structure characteristic of growth hormone and cytokine receptors even in a structure of its transmembranous portion when its structure is determined by a hydrophobicity analysis according to Kyte-Doolittle method; (iii) it is expressed at a high level in a human adult brain, and in less amount in the heart, while it is not expressed in other adult organs or fetus; (iv) it induces programmed cell death (apoptosis) when over-expressed in a cultured human nerve cell lines; (v) it induces termination of cell division and aging when over-expressed in a cultured human normal cell; (vi) it is located in cytoplasm, and forms an intracellular aggregate when overexpressed; and (vii) besides human adult neurons, it is specifically expressed in a human colorectal cancer cell line or in a skin cancer cell line, or an analogue thereof.
REFERENCES:
patent: 5354556 (1994-10-01), Sparks et al.
patent: 5674845 (1997-10-01), MacCuish
patent: 5871973 (1999-02-01), Hillman et al.
patent: 5928899 (1999-07-01), Hillman et al.
T. Mori et al., “Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6.”, Cytogenetics and Cell Genetics, vol. 73, pp. 224-227, 1996.
Takahiro Nagase et al., “Prediction of the Coding Sequences of Unidentified Human Genes. IV. The Coding Sequences of 40 New genes (KIAA0121-KIAA0160) Deduced by Analysis of cDNA Clones from Human Cell Line KG-1.”, DNA Research, col. 2, pp. 167-174, 1995.
Shuichi Nakatsuru et al., “Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae.”, Biochemical and Biophysical Research Communications, vol. 22, No. 1, pp. 82-87, 1994.
Carol Nottenburg et al., “Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences. (Recombinant DNA;cDNA libraries; differential expression; cell surface glycoproteins)”, Gene, vol. 95, pp. 279-284, 1990.
D. Zha et al., “Direct Submission.”, [Journal] Max-Planck Junior Group No. 2, Shanghai Institute of Cell Biology, Sequence Information from Database Provided by NCBI (Entrez) (2 pgs.).
Alberts et al., “Molecular Biology of the Cell, Second Edition”, Cancer 1989 (Chapter 21) p. 1216, Garland Publishing, Inc. New York and London.
Tanaka Manami
Tanaka Tomoo
Andres Janet
Foley & Lardner LLP
Secretary of Agency of Industrial Science and Technology
LandOfFree
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