Human cytoplasmic polyadenylation element binding protein...

Details Human cytoplasmic polyadenylation element binding protein... Human cytoplasmic polyadenylation element binding protein...

2006-05-02

2006-05-02

Wax, Robert A. (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S006120, C435S366000, C435S320100, C536S023100, C536S024300

Reexamination Certificate

active

07037686

ABSTRACT:
The present invention provides genomic and cDNA encoding human cytoplasmic polyadenylation element binding protein, expression vectors comprising human cytoplasmic polyadenylation element binding protein cDNA and host cells that contain the expression vectors. Also provided are recombinant human cytoplasmic polyadenylation element binding protein and polypeptides derived thereof. In addition, the present invention reports that the human Mos 3′ untranslated region (3′ UTR) contains a functional cytoplasmic polyadenylation element (CPE), interacts with the human CPEB1 protein and directs maturation-dependent cytoplasmic polyadenylation of the endogenous Mos mRNA.

REFERENCES:
Welk et al., “Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein,” Genes 263: 113-120, published Jan. 24, 2001.
NCBI GenBank record No. X65305, disclosure of the Promega pGEM®-4Z cloning vector, first submitted Mar. 23, 1992.
Promega Technical Bulletin No. 036, pGEM®-4Z Vector (Feb. 2004).
Sequence alignment, Result 1 from a search of SEQ ID NO: 1 in the GenEmbl database.

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