Human cytomegalovirus immunotherapy

Details Human cytomegalovirus immunotherapy Human cytomegalovirus immunotherapy

2011-07-12

2011-07-12

Mosher, Mary E (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

C424S230100, C530S350000, C435S235100, C536S023720, C536S023400

Reexamination Certificate

active

07976845

ABSTRACT:
An isolated protein construct comprising a polyepitope derived from multiple human cytomegalovirus protein antigen epitopes conjugated to an extracellular domain of glycoprotein B, which isolated protein is capable of eliciting a cytotoxic T-lymphocyte immune response as well as a neutralizing antibody response to human cytomegalovirus. Also provided are pharmaceutical compositions comprising the isolated protein or an adenoviral expression construct for delivery and expression of a nucleic acid encoding the isolated protein for prophylactic and/or therapeutic treatment of human cytomegalovirus infection, particularly in humans.

REFERENCES:
patent: WO 03/000720 (2003-01-01), None
patent: WO 03/000720 (2003-01-01), None
patent: WO 2004/007556 (2004-01-01), None
Carlson et al. “Expression, Purification, and Characterization of a Soluble Form of human Cytomegalovirus Glycoprotein B.” Virology 239:198-205, 1997.
Beninga et al (Journal of General Virology 76:153-160, 1995).
Fields et al (Fields Virology, Third Edition, vol. 2, pp. 2376, 2456; Lippincott Williams & Wilkins, Philadelphia; 1996).
Tanner et al (Journal of Virology 62:4452-4464, 1998).
Strive et al (Journal of Virology 76: 1252-1264, 2002).
Carlson et al (Virology 239:198-205, 1997).
Chou, S et al. 1992 “Comparative analysis of sequence variation in gp116 and gp55 components of glycoprotein B of human cytomegalovirus”Virology188:388-390.
Rist, M et al. 2005 “Ex vivo expansion of human cytomegalovirus-specific cytotoxic T cells by recombinant polyepitope: implications for HCMV immunotherapy”Eur J Immunol35:996-1007.
Spaete, R.R. et al. 1988 “Human cytomegalovirus strain Towne glycoprotein B is processed by proteolytic cleavage”Virology167:207-225.

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