Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1998-10-01
2000-10-10
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
536 232, 4353201, 435 6, 4352523, 43525411, C12N 902
Patent
active
061300772
ABSTRACT:
The invention provides a human cytochrome P450 (HUCYP) and polynucleotides which identify and encode HUCYP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HUCYP.
REFERENCES:
patent: 5886157 (1999-03-01), Guengerich et al.
GenBank Accession No. AA580329, Sep. 1997.
GenBank Accession No. AA393407, Apr. 1997.
GenBank Accession No. N78537, Mar. 1996.
GenBank Accession No. AA094256, Oct. 1996.
ExPASY Enzyme: EC 1.14.14.1 (Sep., 1998).
Prosite: PDOC00081 Cytochrome P450 cysteine heme-iron ligand signature (Nov., 1997).
Prints EP4501 E-Class P450 Group I signature (Mar., 1996).
Graham-Lorence, S. and J.A. Peterson, "P450s: Structural similarities and functional differences," FASEB J., 10:206-214 (1996).
Nebert, D.W. and F.J. Gonzalez, "P450 Genes: Structure, Evolution, and Regulation," Ann. Rev. Biochem., 56:945-993 (1987).
Dogra, S.C. et al., "Transcriptional Activation of Cytochrome P450 Genes by Different Classes of Chemical Inducers," Clin. Exp. Pharmacol. Physiol., 25:1-9 (1998).
Online Mendelian Inheritance in Man (OMIM) *601771 Cytochrome P450, Subfamily I (Dioxin-Inducible), Polypeptide 1; CYP1B1 (Apr., 1997).
Katsung, B.G., Ed., Basic and Clinical Pharmacology, Appleton & Lange, Norwalk, CT, pp. 48-59 (1995).
Morgan, E.T., "Regulation of Cytochromes P450 During Inflammation and Infection," Drug Metab. Rev., 29(4):1129-1188 (1997).
OMIM *240300 Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (Jun., 1986).
Isselbacher, K.J. et al., Harrison's Principles of Internal Medicine, McGraw-Hill, Inc., New York, NY, pp. 1968-1970 (1994).
Takeyama, K. et al., "25-Hydroxyvitamin D.sub.3 1.alpha.-Hydroxylase and Vitamin D Synthesis," Science, 227:1827-1830 (1997).
Kitanaka, S. et al., "Inactivating Mutations in the 25-Hydroxyvitamin D.sub.3 1.alpha.-Hydroxylase Gene in Patients with Pseudovitamin D-Deficiency Rickets," N. Engl. J. Med., 338(10):653-661 (1998).
OMIM *213700 Cerebrotendinous Xanthomatosis (Jun., 1986).
OMIM #122700 Coumarin Resistance (Jun., 1986).
Agarwal, V.R. et al., "Molecular Basis of Severe Gynecomastia Associated with Aromatase Expression in a Fibrolamellar Hepatocellular Carcinoma," J. Clin. Endocrinol. Metab., 83(5):1797-1800 (1998).
Waxman, D.J., "P450-Catalyzed Steroid Hydroxylation: Assay and Product Indentification by Thin-Layer Chromatography," Methods Enzymol., 206:462-476 (1991).
Au-Young Janice
Corley Neil C.
Guegler Karl J.
Yue Henry
Achutamurthy Ponnathapu
Incyte Pharmaceuticals Inc.
Kerr Kathleen
LandOfFree
Human cytochrome P450 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human cytochrome P450, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human cytochrome P450 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2255416