Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-11-05
2000-01-04
Mertz, Prema
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, 435 691, 435 712, 435325, 4352523, 4353201, 435471, C07K 1447, C12N 1512, A61K 3817
Patent
active
060110120
ABSTRACT:
Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachicia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
REFERENCES:
patent: 5212297 (1993-05-01), Colella et al.
patent: 5432264 (1995-07-01), Grubb et al.
Harlow et al. (1988) Antibodies, A Laboratory Manual, Cold Spring Harbor Laboratory. p. 76, ch. 5.
Cunningham et al. (1989) Science vol. 244, pp. 1081-1085.
George et al. (1988) Macromolecular Sequencing & Synthesis, Alan R. Liss, Inc. N.Y. CH. 12, pp. 127-149.
Esnard et al. (1988) FEBS Letters, vol. 236, No. 2, pp. 475-478.
Journal of Biological Chemistry, vol. 266, No. 30, Oct. 25, 1991, Freije et al, "Structure and Expression of the Gene Encoding Cystatin D, a Novel Human Cysteine Proteinase Inhibitor." pp. 20538-20543.
Gene, vol. 61, 1987, Saitoh et al, "Human Cystein-Proteinase Inhibitors: Nucleotide Sequence Analysis of Three Members of the Cystatin Gene Family." pp. 329-338.
Biochem. Biophys. Res. Comm., vol. 162, No. 3, Aug. 15, 1989, Saitoh et al, "The Human Cystatin Gene (CST3) is a Member of the Cystatin Gene Family Which is Localized in Chromosome 20." pp. 1324-1331.
European Journal of Biochemistry, vol. 186, 1989, Cole et al, "The cDNA Structure and Expression Analysis of the Genes for the Cysteine Proteinase Inhibitor Cystatin C and for .beta.2-Microglobulin in Rat Brain." pp. 35-42.
Science, vol. 271, Mar. 22, 1996, Pennacchio et al, "Mutationss in the Gene Encoding Cystatin B in Progressive Myoclonus Epilepsy (EPM1)." pp. 1731-1733.
Genbank Accession No. U62800, "Identification, Cloning and Characterization of Cystatin M, a Novel Cysteine Proteinase Inhibitor, Down-Regulated in Breast Cancer." Available to public, Aug. 24, 1996, Sotiropoulou G. et al. J. Biol. Chem (1997) vol. 272, No. 2, pp. 903-910.
Gentz Reiner L.
Ni Jian
Rosen Craig A.
Yu Guo-Liang
Brookes A. Anders
Human Genome Sciences Inc.
Mertz Prema
LandOfFree
Human cystatin E does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human cystatin E, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human cystatin E will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1072695