Human cyclin I and genes encoding same

Details Human cyclin I and genes encoding same Human cyclin I and genes encoding same

2006-02-21

2006-02-21

Canella, Karen A. (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S350000, C530S827000

Reexamination Certificate

active

07001985

ABSTRACT:
This invention relates to a novel protein having a high degree of homology to the amino acid sequence of the so-called cyclin box which is characteristic of cyclins: they are herein referred to as “human cyclin I” or “human cyclin I protein.” Further, the invention relates to a gene encoding their amino acid sequences and the protein: the gene is referred to as “gene encoding human cyclin I” or “human cyclin I gene.” Also, the invention relates to expression vector into which the human cyclin I gene is incorporated as well as to a transformant into which the vector is introduced. Still further, the invention relates to a recombinant protein obtained by growing the transformant. In addition, the invention relates to a novel neuron-marking method using an anitisense nucleotide of the gene as probe. Furthermore, the invention relates to method for screening cancer cell using the human cyclin I gene.

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patent: 94/09135 (1994-04-01), None
patent: PCT96/02905 (1996-10-01), None
No reference cited.
Nakamura T. et al. “Cyclin I: A New Cyclin Encoded by a Gene Isolated from Human Brain” Exp. Cell. Res. (Dec. 1995) vol. 221, No. 2, pp. 534-542.
Robert P.F. et al. “A Novel Cyclin Associates with M015/CDK7 to Form the CDK-Activating Kinase” Cell (1994) vol. 78, pp. 713-724.
Jonathon P. et al. Isolation of a Human Cyclin cDNA: Evidence for Cyclin mRNA and Protein Regulation in the Cell Cycle and for Interaction with p34cdc2Cell (1989), vol. 58, pp. 833-846.
Tony Hunter et al., “Cyclins and Cancer”, The Salk Institute, Cell, vol. 66, pp. 1071-1074, Sep. 20, 1991.
John Lew et al., “Neuronal cdc2-like Kinase”, TIBS 20, Reviews, Elsevier Science Ltd., pp. 33-37, Jan. 1995.
Tony Hunter et al., “Cyclins and Cancer II: Cyclin D and CDK Inhibitors Come of Age”, The Salk Institute, Cell, vol. 79, pp. 573-582, Nov. 18, 1994.
Tamura et al., “Cyclin G: A New Mammalian Cyclin with Homology to Fission Yeast Cig 1”, Research Institute for Microbial Diseases, Oncogene (1993), 8, pp. 2113-2118.
Hiroshi Matsushime, “Interaction Between Cyclins and cdks”, Experimental Medicine, vol. 13, No. 6 (special number) 1995, pp. 1-2.
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Daniel J. Lew et al., “Isolation of Three Novel Human Cyclins by Rescue of G1 Cyclin (CIn) Function in Yeast”, The Scripps Research Institute, Cell, vol. 66, pp. 1197-1206, Sep. 20, 1991.

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