Human cyclin E polypeptides

Details Human cyclin E polypeptides Human cyclin E polypeptides

1995-06-07

1998-07-21

Arthur, Lisa B.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530350, 536 235, C07K 500, C07K 1400, C07H 2104

Patent

active

057836612

ABSTRACT:
Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 1 and 1185 of the human cyclin E cDNA sequence shown in FIG. 2. Polypeptides encoded by such nucleic acid molecules, and immunologic binding partners directed to such polypeptides.

REFERENCES:
patent: 5449755 (1995-09-01), Roberts et al.
patent: 5543291 (1996-08-01), Keyomarsi et al.
Arion, D., Meijer, L., Brizuela, L., and Beach, D. (1988). cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell 55, 371-378.
Cross, F. (1988). DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol. Cell. Biol. 8, 4675-4684.
Cross, F. (1990). Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-1 arrest and is independent of the mating-pheromone signalling pathway. Molec. Cell. Biol. 10, 6482-6490.
Draetta, G., and Beach, D. (1988). Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54, 17-26.
Draetta, G., Luca, F., Westendorf, J., Brizuela, L. Ruderman, J., and Beach, D. (1989). cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 56, 829-838.
Dunphy, W.G., Brizuela, L., Beach, D., and Newport, J. (1988). The Xenopus cdc2 protein is a component of mpf, a cytoplasmic regulator of mitosis. Cell 54, 423-431.
D'Urso, G., Marraccino, R.L., Marshak, D.R., and Roberts, J.M. (1990). Cell cycle control of DNA replication by a homologue from human cells of the p34.sup.cdc2 protein kinase. Science 250, 786-791.
Evans, T., Rosenthal, E.T., Youngblom, J., Disten, D., and Hunt, T. (1983). Cyclin: a protein specified by maternal mRNA in sea urchin egg that is destroyed at each cleavage division. Cell 33, 389-296.
Furakawa, Y., Piwnica-Worms, H., Ernst, T.J., Kanakura, Y., and Griffin, J.D. (1990). cdc2 gene expression at the G.sub.1 to S transition in human T lymphocytes. Science 250, 805-808.
Gautier, J., Norbury, C., Lohka, M., Nurse, P., and Maller J.L. (1988) Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2.sup.+. Cell 54, 433-439.
Gautier, J., Minshull, J., Lohka, M., Glotzer, M., Hunt, T., and Maller, J.L. (1990). Cyclin is a component of maturation-promoting factor from Xenopus. Cell 60, 487-494.
Hadwiger, J.A., Wittenberg, C., Richardson, H.E., Lopes, M.dB., and Reed, S.I. (1989). A family of cyclin homologs that control the G.sub.1 phase in yeast. Proc. Natl. Acad. Sci. USA 86, 6255-6259.
Hunt, T. (1989). Maturation promoting factor, cyclin and the control of M-phase. Curr. Opin. Cell Biol. 1, 268-274.
Labbe, J.C., Lee, M.G., Nurse, P., Picard, A., and Doree, M. (1988). Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle gene cdc2. Nature 335, 251-254.
Labbe, J.C., Capony, J.P., Caput, D., Cavadore, J.C., Derancourt, J., Kaghad, M., Lelias, J.M., Picard, A., and Doree, M. (1989a). MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B. EMBO J. 8, 3053-3058.
Labbe, J.C., Picard, A., Peaucellier, G., Cavadore, J.C., Nurse, P., and Doree, M. (1989b). Purification of MPF from starfish: identification as the H1 histone kinase p34.sup.cdc2 and a possible mechanism for its periodic activation. Cell 57, 253-263.
Lee, M.G., and Nurse, P. (1987). Coplementation used to clone a human homologue of fission yeast cell cycle control gene cdc2. Nature 327, 31-35.
Meijer, I., Arion, D., Golsteyn, R., Pines, J., Brizuela, L., Hunt, T., and Beach, D. (1989). Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. EMBO J. 8, 2275-2282.
Minshull, J., Blow, J.J., and Hunt, T. (1989). Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis. Cell 56, 947-956.
Murray, A.W., and Kirschner, M.W. (1989). Cyclin synthesis drives the early embryonic cell cycle. Nature 339, 275-280.
Nash, R., Tokiwa, G., Anand, S., Erickson, K., and Futcher, A.B. (1988). The WHI gene of Saccharomyces cerivisae tethers cell division to cell size and is a cyclin homolog. EMBO J. 7, 4335-4346.
Nurse, P. (1990). Universal control mechanism regulating onset of M-phase. Nature 344, 503-508.
Nurse, P. and Bisset, Y. (1981). Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 292, 558-560.
Pardee, A.B. (1989). G1 events and regulation of cell proliferation. Science 246, 603-608.
Piggot, J.R., Rai, R., and Carter, B.L.A. (1982). A bifunctional gene product involved in two phases of the yeast cell cycle. Nature 298, 391-393.
Pines, J., and Hunter, T. (1989). Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34.sup.cdc2. Cell 58, 833-846.
Rao, P.N., and Johnson, R.T. (1970). Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature 225, 159-164.
Reed, S.I., and Wittenberg, C. (1990). Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87, 5697-5701.
Riabowol, K., Draetta, G., Brizuela, L., Vandre, D., and Beach, D. (1989). The cdc kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57, 393-401.
Richardson, H.E., Wittenberg, C., Cross, F., and Reed, S.I. (1989). An essential G1 function for cyclin-like proteins in yeast. Cell 59, 1127-1133.
Rosenthal, E.T., Hunt, T., and Ruderman, J.V. (1980). Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima. Cell 20, 487-494.
Soloman, M., Glotzer, M., Lee, T.H., Phillippe, M., and Kirschner, M.W. (1990). Cyclin activation of p34.sup.cdc2. Cell 63, 1013-1024.
Sudbery, P.E., Goodey, A.R., and Carter, B.L. (1980). Genes which control cell proliferation in the yeast Saccharomyces cerevisiae. Nature (London) 288, 401-404.
Swenson, K.I., Farrell, K.M., and Runderman, J.V. (1986). The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes. Cell 47, 861-870.
Wittenberg, C., and Reed, S.I. (1989). Conversion of function and regulation within the Cdc28/cdc2 protein kinase family: Characterization of the human Cdc2HS protein kinase in Saccharomyces cerevisiae. Mol. Cell Biol. 4064-4068.
Wittenberg, C., Sugimoto, K., and Reed, S.I. (1990). G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34.sup.CDC28 protein kinase. Cell 62, 225-237.
Zetterberg, A. (1990). Control of mammalian cell proliferation. Curr. Opin. Cell Biol. 2, 296-300.
Zetterberg, A., and Larson, O. (1985). Kinetic analysis of regulatory events in G1 leading to proliferation of quiescence of Swiss 3T3 cells. Proc. Natl. Acad. Sci. USA 82, 5365-5369.
Nasmyth, K.A.(1990). FAR-reaching discoveries about the regulation of START. Cell 63, 1117-1120.
Roberts, J. (1991). Assembly of cyclin/CDC2 complexes during the G1 phase of the cell cycle and their role in activating DNA synthesis. Cold Spring Harbor Laboratory, p. 126.
Beach, D., Durkacz, B., and Nurse, P. (1982). Functionally homologous cell cycle control genes in fission yeast and budding yeast. Nature 300, 706-709.
Blow, J.J., and Nurse, P. (1990). A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts. Cell 62, 855-862.
Booher, R., and Beach, D. (1987). Interaction between cdc13.sup.+ and cdc2 in the control of mitosis in fission yeast; dissociation of the G.sub.1 and G.sub.2 roles of the cdc2.sup.+ protein kinase. EMBO J. 6, 3441-3447.
Broek, D., Bartlett, R., Crawford, K., and Nurse, P. (1990). Involvement of p34.sup.cdc2 in establishing the dependency of S phase on mitosis. Nature 349, 388-393.
Giordano, A., Whyte, P., Harlow, E., Franza, Jr., B.R., Beach, D., and Draetta, G. (1989). A

Affiliated with

Also associated with

Rating

Human cyclin E polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human cyclin E polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human cyclin E polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1647822