Human corneal epithelial cell lines with extended lifespan

Chemistry: molecular biology and microbiology – Spore forming or isolating process

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 721, C12N 500

Patent

active

056724985

ABSTRACT:
The present invention provides human corneal epithelial cell lines with extended lifespan. The cell lines are useful as an in vitro model of the human ocular surface. Methods for making and using the cell lines are also provided.

REFERENCES:
patent: 4707448 (1987-11-01), Major
patent: 4760020 (1988-07-01), Neufeld et al.
patent: 4808532 (1989-02-01), Stampfer
patent: 4835102 (1989-05-01), Bell et al.
patent: 4885238 (1989-12-01), Reddel et al.
patent: 5374515 (1994-12-01), Parenteau et al.
Linder et al., Exp. Cell Res., vol. 191, 1990, pp. 1-7.
In Vitro Toxicity Testing, edited by J.M. Frazier, "Draize Eye Irritation Test" p. 160.
"Cultured Epithelial Cells of Cornea, Conjunctiva and Skin: Absence of Marked Intrinsic Divergence of Their Differentiated States", Tung-Tien Sun et al, Nature, vol. 269, No. 5628, pp. 489-493, Oct. 6, 1977.
"Neoplastic Transformation of Human Epidermal Keratinocytes by AD12-SV40 and Kirsten Sarcoma Viruses", Johng S. Rhim et al, Science, Mar. 8, 1985, vol. 227, pp. 1250-1252.
"Characterization of Human Uroepithelial Cells Immortalized in Vitro by Simian Virus 40", Brian J. Christian et al, Cancer Research 47, 6066-6073, Nov. 15, 1987.
"Establishment and Characterization of SV40 T-Antigen Immortalized Human Esophageal Epithelial Cells", Stoner et al, Cancer Research, 51, 365-371, Jan. 1, 1991.
"Immortalization of Human Tracheal Gland Epithelial Cells by Adenovirus 12-SV40 Hybrid Virus", Letter to the Editor by Chopra et al, In Vitro Cell Dev. Biol. 27A:763-765, Oct. 1991.
"Cloning of cDNAs for Cellular Proteins that Bind to the Retinoblastoma Gene Product", D. Defeo-Jones et al, Nature, vol. 352, Jul. 18, 1991, pp. 251-254.
"Expression of SV-40 T Antigen in the Small Intestinal Epithelium of Transgenic Mice Results in Proliferative Changes in the Crypt and Reentry of Villus-associated Enterocytes into the Cell Cycle but Has no Apparent Effect on Cellular Differentiation Programs and Does Not Cause Neoplastic Transformation", Sherrie M. Hauft et al, The Journal of Cell Biology, vol. 117, No. 4, May 1992, pp. 825-839.
"In Vitro Test Validation: A House Built on Sand", Editorial, ATLA 20, pp. 196-198, 1992.
"Malignant Human Papillomavirus Type 16-transformed Human Keratinocytes Exhibit Altered Expression of Extracellular Matrix Glycoproteins", N. Sheibani et al, Cancer Research 51, 5967-5975, Nov. 1, 1991.
"Neoplastic Transformation of Human Epithelial Cells in Vitro", J. Rhim, AntiCancer Research 9, pp. 1345-1366, 1989.
"Isolation and Characterization of a Transformed Human Corneal Epithelial-Like Cell Line", H.V. Chaves et al., Journal of Investigative Ophthalmology and Visual Science vol. 32, No. 4, p. 1072, 1991.
"Generation and Morphological Characterization of Human Corneal Epithelial Primary Cultures and Immortalized Cell Lines in Serum Free Medium: Potential Model for Ocular Studies" C. Khan et al., Journal of Investigation Ophthalmology and Visual Science vol. 33, No. 4, p. 1176, 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human corneal epithelial cell lines with extended lifespan does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human corneal epithelial cell lines with extended lifespan, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human corneal epithelial cell lines with extended lifespan will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2256074

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.