Human coagulation factor VII variants

Details Human coagulation factor VII variants Human coagulation factor VII variants

2005-06-14

2005-06-14

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C530S381000

Reexamination Certificate

active

06905683

ABSTRACT:
The invention concerns novel coagulation factor VII variants, wherein the Leu residue in position 305 or the Phe residue in position 374 of SEQ ID NO 1 has been replaced by another amino acid residue which can be encoded by nucleic acid constructs and, optionally, wherein at least one other amino acid residue in the remaining positions in the protease domain has been replaced by another amino acid residue which can be encoded by nucleic acid constructs;with the proviso that the variant is not FVII(Ala305).The invention further concerns nucleic acids encoding the Factor VII variants; vectors and cells comprising the nucleic acid; methods for producing the variants; pharmaceutical compositions comprising a Factor VII variant wherein the Leu residue in position 305 or the Phe residue in position 374 of SEQ ID NO 1 has been replaced by another amino acid residue which can be encoded by nucleic acid constructs and, optionally, wherein at least one other amino acid residue in the remaining positions in the protease domain has been replaced by another amino acid residue which can be encoded by nucleic acid constructs; use of the variants for producing a medicament for treatment or prophylaxis of bleeding disorders or enhancement of the coagulation system; and methods of treatment.

REFERENCES:
patent: 5288629 (1994-02-01), Berkner
patent: 5580560 (1996-12-01), Nicolaisen et al.
patent: 5874407 (1999-02-01), Kelley et al.
patent: 5994296 (1999-11-01), Ruf et al.
patent: 2003/0096338 (2003-05-01), Pedersen et al.
patent: 2003/0130191 (2003-07-01), Persson et al.
patent: 2003/0170863 (2003-09-01), Persson et al.
patent: 0 200 421 (1986-12-01), None
patent: 10/59866 (1998-03-01), None
patent: 2001 061479 (1999-08-01), None
patent: 88/10295 (1987-06-01), None
patent: 94/07515 (1992-10-01), None
patent: 94/27631 (1994-05-01), None
patent: 97/20939 (1996-11-01), None
patent: 98/31394 (1998-01-01), None
patent: 01/58935 (2001-08-01), None
patent: 01/75086 (2001-10-01), None
patent: 01/82943 (2001-11-01), None
patent: 01/83725 (2001-11-01), None
patent: 01/85198 (2001-11-01), None
patent: 02/22776 (2002-03-01), None
patent: 02/38162 (2002-05-01), None
patent: 02/062376 (2002-08-01), None
patent: 02/077218 (2002-10-01), None
patent: 03/027147 (2003-04-01), None
Dictionary of Biochemistry and Molecular Biology (John Wiley & Sons, 2d ed. 1989).
U.S. Appl. No. 60/184,036, filed Feb. 22, 2000.
Neuenschwander et al., Biochemistry, vol. 34, pp. 8701-8707 (1995).
Bernardi et al., Human Mutation, vol. 8, pp. 108-115 (1996).
Chang et al., Biochemistry, vol. 38, pp. 10940-10948 (1999).
Leonard et al., Abstract 1474, Journ of Int Soc Thromb and Haemost., p. 466 (Suppl. Aug. 1999).
Iakhiev et al., Thromb and Haemost, vol. 85 (3), pp. 458-463 (2001).
Jin et al., Journ of Mol Bio, vol. 307 (part 5), pp. 1503-1517.
Persson et al., Journ of Biol Chem, vol. 276 (31), pp. 29195-29199 (2001).
Peyvandi et al., Throm Haemost, vol. 84, pp. 250-257 (2000).
Peyvandi et al., Throm Haemost, vol. 88, pp. 750-755 (2002).
Soejima et al., Jorun of Bio Chem, vol. 276 (20), pp. 17229-17235 (2001).
U.S. Appl. No. 10/415,963, filed May 5, 2003, Ruf et al.
Dickinson et al., Biochemistry, vol. 93, pp. 14379-14384 (1996).
Abstract of Mizuguchi et al., Journal of the International Society on Thrombosis and Haemostasis, p. 466 (Supplement 1999).
Abstract of Jianping Jin, Ph.D., Dissertation Abstracts International, vol. 60, No. 12-B, p. 5929 (1999).
Abstract of Kumar A. Fair, D.S., European Journal of Biochemistry (Germany), vol. 217, No. 2, pp. 509-518 (1993).

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