Human chromosome 16 genes, compositions, methods of making and u

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 6, 435 691, 435 701, 435 711, 435325, 435375, 4353201, 536 235, 536 2431, 536 2433, 935 9, 935 22, 935 34, 935 52, 935 66, 800 9, 800 13, 800 14, 800 21, C12P 2106, C12P 2102, C12N 510, C07H 2104

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060308060

ABSTRACT:
In accordance with the present invention, there are provided isolated nucleic acids encoding a human netrin, a human ATP binding cassette transporter, a human ribosomal L3 subtype, and a human augmenter of liver regeneration as well as isolated protein products encoded thereby. The present invention provides nucleic acid probes that hybridize to invention nucleic acids as well as isolated nucleic acids comprising unique gene sequences located on chromosome 16. Further provided are vectors containing invention nucleic acids, host cells transformed therewith, as well as transgenic non-human mammals that express invention polypeptides. The present invention includes antisense oligonucleotides, antibodies and compositions containing same. Additionally, the invention provides methods for identifying compounds that bind to invention polypeptides.

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