Human chondromodulin-I protein

Details Human chondromodulin-I protein Human chondromodulin-I protein

1994-05-11

1998-02-17

Ulm, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530399, 435 691, 4353201, 4352523, 435325, A61K 3817

Patent

active

057191255

ABSTRACT:
A novel human chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF, promoting the differential potency of these cells, and inhibiting the growth of vascular endothelial cells, a DNA encoding this protein, expression vector containing the DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing the transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

REFERENCES:
patent: 5444157 (1995-08-01), Suzuki et al.
Takigawa et al. Anticancer Res. (1990) 10, 311-316.
Hiraki et al. Biochem. Biophys. Res. Comm. (1991) 175, 971-977.
Chemical Abstracts, vol. 115, No. 15, Oct. 14, 1991, Y. Hiraki et al., "Molecular Cloning of a New Class of Cartilage-Specific Matrix, Chondromodulin-I, Which Stimulates Growth of Cultured Chondrocytes", p. 270.

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