Human choline acetyltransferase

Details Human choline acetyltransferase Human choline acetyltransferase

2006-08-01

2006-08-01

Patterson, Jr., Charles L. (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S015000, C435S193000

Reexamination Certificate

active

07083930

ABSTRACT:
Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.

REFERENCES:
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McGeer et al., “Choline Acetyltransferase: Purification and Immunohistochemical Localization,”Life Sciences,34:2319-2338 (1984).
Strauss et al., “Cloning of a Human Choline Acetyltransferase cDNA,” Soc. for Neuroscience Abstracts, 11(2):1114 (1985).
Hersh et al., Isolation of a Genomic Clone of Human Choline Acetyltransferase,Klinische Pharmakologie,2:15-19 (1989).
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Fann et al., “A novel approach to screen for cytokine effects on neuronal gene expression,”J. Neurochem.,61(4):1349-1355 (Oct. 1993).
Li et al., “Cholinergic Neuron-Specific Expression of the Human Choline Acetyltransferase Gene Is Controlled by Silencer Elements”,J. Neurochem.,61:748-751 (1993).
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Corti et al., “Molecular Cloning of cDNAs Encoding Human Carnitine Acetyltransferase and Mapping of the Corresponding Gene to Chromosome 9q34.1,”Genomics,23(1):94-99 (Sep. 1, 1994).
Esser et al., “Cloning, Sequencing, and Expression of cDNA Encoding Rat Liver Carnitine Palmitoyltransferase I—Direct Evidence that a Single Polypeptide is Involved in Inhibitor Interaction and Catalytic Function,”J. Biol. Chem.,268(8):5817-5822 (Mar. 15, 1993).
GenBank Accession No. A55720, Corti et al., “carnitine O-acetyltransferase (EC 2.3.1.7) precursor, mitochondrial—human,” Mar. 23, 1995.
GenBank Accession No.H15198, Hillier et al., “ym30c04.r1 Soares infant brain INIBHomo sapienscDNA clone Image:49788 5' similar to gb:S56138 Choline O-Acetyltransferase (Human), mRNA sequence,” Jun. 27, 1995.
GenBank Accession No. R99408, Hillier et al., “yq71g08.r1 Soares fetal liver spleen 1 NFLSHomo sapienscDNA clone Image:201278 5' similar to SP:CLAT—Human P28329 Choline O-Acetyltransferase, mRNA sequence,” Sep. 14, 1995.
GenBank Accession No. R73196, Hillier et al., “yj91e06.r1 Soares breast 2NbHBstHomo sapienscDNA clone Image:156130 5' similar to SP:CLAT—Human P28329 Choline O-Acetyltransferase, mRNA sequence,” Jun. 2, 1995.
GenBank Accession No. T71117, Hillier et al., “yc50g07.r1 Stratagene liver (#937224)Homo sapienscDNA clone Image:84156 5' similar to SP:CLAT—Human P28329 Choline O-Acetyltransferase, mRNA sequence,” Mar. 1, 1995.
GenBank Accession No. R08221, Hillier et al., “yf18b06.r1 Soares fetal liver spleen 1NFLSHomo sapienscDNA clone Image:127187 5' similar to gb:S56138 Choline O-Acetyltransferase (Human), mRNA sequence,” Apr. 5, 1995.
GenBank Accession No. R11960, Hillier et al., “yf54f05.r1 Soares infant brain 1NIBHomo sapienscDNA clone Image:25856 5' similar to SP:CLAT—DROME P07668 Choline O-Acetyltransferase , mRNA sequence,” Apr. 11, 1995.

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