Human chitinase, its recombinant production, its use for decompo

Details Human chitinase, its recombinant production, its use for decompo Human chitinase, its recombinant production, its use for decompo

1998-09-10

2000-05-02

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352523, 435325, 4353201, 536 232, C12N 121, C12N 510, C12N 1556, C12N 942

Patent

active

06057142&

ABSTRACT:
A new human chitinase having an amino acid sequence as shown in FIG. 1 or FIG. 2. Modified forms of it having a similar chitin-hydrolyzing activity, and antigenic peptides representing one of its epitopes. Recombinant production of the human chitinase by genetically engineered hosts or host cells. Recombinant nucleic acid encoding it, and human chitinase-specific oligonucleotides. Use for therapeutic or prophylactic treatment of humans against infection by chitin-containing pathogens, or for decomposing chitin, e.g. from chitin-based articles. Antibodies binding to the human chitinase. Diagnostic test kits comprising the human chitinase, its antigenic peptides, human chitinase antibodies, recombinant nucleic acid or oligonucleotides.

REFERENCES:
Boot et al., The Journal of Biological Chemistry 270 (44):26252-26256 (Nov. 1995).
Renkema et al., The Journal of Biological Chemistry 270 (5):2198-2202 (Feb. 1995).
Hakala et al., The Journal of Biological Chemistry 268 (34): 25803-25810 (Dec. 1993).
Kramer et al., Insect Biochemistry and Molecular Biology 23(6) :691-701 (1993). Abstract only.
1988 Stratagene Catalog, p. 39 (1988).

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