Human chitinase, its recombinant production, its use for decompo

Details Human chitinase, its recombinant production, its use for decompo Human chitinase, its recombinant production, its use for decompo

1995-06-07

1999-07-27

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

530350, 435183, 536 231, 536 243, C12N 926, C12N 900, C07K 1400, C07H 2102

Patent

active

059289287

ABSTRACT:
A new human chitinase having an amino acid sequence as shown in FIG. 1 or FIG. 2. Modified forms of it having a similar chitin-hydrolyzing activity, and antigenic peptides representing one of its epitopes. Recombinant production of the human chitinase by genetically engineered hosts or host cells. Recombinant nucleic acid encoding it, and human chitinase-specific oligonucleotides. Use for therapeutic or prophylactic treatment of humans against infection by chitin-containing pathogens, or for decomposing chitin, e.g. from chitin-based articles. Antibodies binding to the human chitinase. Diagnostic test kits comprising the human chitanase, its antigenic peptides, human chitinase antibodies, recombinant nucleic acid or oligonucleotides.

REFERENCES:
Kramer et al., Insect Biochemistry and Molecular Biology 23(6) : 691-701 (1993). Abstract Only.
Boot et al., The Journal of Biological Chemistry 270 (44) : 26252-26256 (Nov. 1995).
Renkema et al., The Journal of Biological Chemistry 270 (5) : 2198-2202 (Feb. 1995).
Hakala et al., The Journal of Biological Chemistry 268 (34) : 25803-25810 (Dec. 1993).
The Stratagene Catalog, p.39 (1988).

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