Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1996-10-08
1999-03-09
Kemmerer, Elizabeth C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530397, 530399, 530395, C07K 1452, C07K 1400
Patent
active
058802630
ABSTRACT:
A human chemotactic protein polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating for stem cell mobilization, myeloprotection and neuronal protection, to treat tumors, to promote wound healing, to combat parasitic infection and to regulate hematopoiesis. Also disclosed are antagonists against such polypeptides which may be employed to treat rheumatoid arthritis, lung inflammation, allergy, infectious diseases and to prevent inflammation and atherosclerosis. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
REFERENCES:
patent: 5179078 (1993-01-01), Rollins et al.
Bowie et al. Science 247:1306-1310. 1990.
Wells. Biochemistry 29:8509-8517. 1990.
Ngo et al. The Protein Folding Problem and Tertiary Structure Prediction. Merz et al., eds., Birkhauser, Boston, pp. 491-495. 1994.
Rudinger. Peptide Hormones. Parsons, ed., University Park Press, Baltimore, pp. 1-7. 1976.
Beall, C.J. et al., "Conversion of Monocyte Chemoattractant Protein-1 Into a Neutrophil Attractant by Substitution of Two Amino Acids," J. Biol. Chem. 267:3455-3459 (1992).
Bischoff, S.C. et al., "Monocyte Chemotactic Protein 1 Is a Potent Activator of Human Basophils," J. Exp. Med. 175:1271-1275 (1992).
Bottazzi, B. et al., "A chemoattractant expressed in human sarcoma cells (tumor--derived chemotactic factor, TDCF) is identical to monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF)," Int. J. Cancer 45:795-797 (1990).
Brieland, J.K. et al., "Effect of Acute Inflammatory Lung Injury on the Expression of Monocyte Chemoattractant Protein-1 (MCP-1) in Rat Pulmonary Alveolar Macrophages," Am. J. Respir. Cell Mol. Biol. 7:134-139 (1992).
Brieland, J.K. et al., "Expression of Monocyte Chemoattractant Protein-1 (MCP-1) by Rat Alveolar Macrphages during Chronic Lung Injury," Am. J. Respir. Cell Mol. Biol. 9:300-305 (1993).
Brown, Z. et al., "IL-1 Receptor Antagonist Inhibits Monocyte Chemotactic Peptide-1 Generation by Human Mesangial Cells," Kidney Int. 42:95-101 (1992).
Cerdote, P. et al., "Cholecystokinin and the Immune System: Receptor-Mediated Chemotaxis of Human Rat Monocytes," Peptides 9(1):29-34 (1988).
Colditz, I. et al., "In Vivo Inflammatory Activity of Neutrophil-Activating Factor, a Novel Chemotactic Peptide Derived from Human Monocytes," Am. J. Pathology 134(4):755-760 (1989).
Decock, B. et al., "Identification Of The Monocyte Chemotactic Protein From Human Osteosarcoma Cells And Monocytes Detection Of A Novel N-Terminally Processed Form," Biochem. Biophys. Res. Comm. 167(3):904-909 (1990).
Furutani, Y. et al., "Cloning And Sequencing Of The cDNA For Human Monocyte Chemotactic And Activating Factor (MCAF)," Biochem. Biophys. Res. Comm. 159(1):249-255 (1989).
Gronenborn, A.M. et al., "Modeling the three-dimensional structure of the monocyte chemoattractant and activating protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8," Prot. Engin. 4(3):263-269 (1991).
Jose, P.J. et al., "Eotaxin: A Potent Eosinophil Chemoattractant Cytokine Detected in a Guinea Pig Model of Allergic Airways Inflammation," J. Exp. Med. 179:881-887 (1994).
Kao. J. et al., "Endothelial Monocyte-activating Polypeptide II," J. Biol. Chem. 267(28):20239-20247 (1992).
Kawahara, R.S. et al., "Platelet-derived Growth Factor-inducible Gene JE Is a Memebr of a Family of Small Inducible Genes Related to Platelet Factor 4," J. Biol. Chem. 264(2):679-682 (1989).
Koch, A.E. et al., "Enhanced Production of Monocyte Chemoattractant Protein-1 in Rheumatoid Arthritis," J. Clin. Invest. 90:772-779 (1992).
Kuna, P. et al., "Monocyte Chemotactic and Activating Factor Is a Potent Histamine-releasing Factor for Human Basophils," J. Exp. Med. 175:489-493 (1992).
Matsushima, K. et al., "Molecular Cloning Of A Human Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF) And The Induction of MDNCF mRNA By Interleukin 1 And Tumor Necrosis Factor," J. Exp. Med. 167(6):1883-1893 (1988).
Matsushima, K. et al., "Purification And Characterization Of A Novel Monocyte Chemotactic And Activating Factor Produced By A Human Myelomonocytic Cell Line, " J. Exp. Med. 169:1485-1490 (1989).
Mehrabian, M. et al., "Localization of Monocyte Chemotactic Protein-1 Gene (SCYA2) to Human Chromosomes 17q11.2-q21.1," Genomics 9:200-203 (1991).
Minty, A. et al., "Molecular Cloning of the MCP-3 Chemokine Gene and Regulation of its Expression," Eur. Cytokine Netw. 4:99-110 (1993).
Morgan, J.G. et al., "Cloning Of The cDNA For The Serine Protease Homolog CAP37/Azurocidin, A Microbicidal And Chemotactic Protein From Human Granulocytes," J. Immunol. 147(9):3210-3214 (1991).
Nelken, N.A. et al., "Monocyte Chemoattractant Protein-1 in Human Atheromatous Plaques," J. Clin. Invest. 88:1121-1127 (1991).
Opdenakker, G. et al., "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines," Biochem. Biophys. Res. Comm. 191(2):535-542 (1993).
Pereira, H.A. et al., "CAP37, a Human Neutrophil-derived Chemotactic Factor with Monocyte Specific Activity," J. Clin. Invest. 85:1468-1476 (1990).
Ransohoff, R.M. et al., "Astrocyte expression of mRNA endocing cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis," FASEB Journal 7(6):592-600 (1993).
Robinson, E.A. et al., "Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions," Proc. Natl. Acad. Sci. USA 86:1850-1854 (1989).
Rolfe, M.W. et al., "Expression and regulation of human pulmonary fibroblast-derived monocyte chemotactic peptide-1," Am. J. Physiology 263(5):L536-L545 (1992).
Rollins, B.J. et al., "Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties," Proc. Natl. Acad. Sci. USA 85:3738-3742 (1988).
Rollins, B.J. et al., "The Human Homolog of the JE Gene Encodes a Monocyte Secretory Protein," Mol. Cell. Biol. 9(11):4687-4695 (1989).
Russell, M.E. et al., "Early and persistent induction of monocyte chemoattractant protein 1 in rat cardiac allografts," Proc. Natl. Acad. Sci. USA 90:6086-6090 (1993).
Sacerdote, P. et al., "Cholecystokinin and the Immune System: Receptor-Mediated Chemotaxis of Human and Rat Monocytes," Peptides 9(suppl. 1):29-34 (1988).
Schall, T.J., "Biology of the RANTES/SIS Cytokine Family," Cytokine 3(3):165-183 (1991).
Shyy, Y. et al., "Structure of Human Monocyte Chemotactic Protein Gene and Its Regulation by TPA," Biochem. Biophys. Res. Comm. 169(2):346-351 (1990).
Strieter, R.M. et al., "Disparate Gene Expression of Chemotactic Cytokines by Human Mononuclear Phagocytes," Biochem. Biophys. Res. Comm. 166(2):886-891 (1990).
Van Damme, J. et al., "Production and identification of natural monocyte chemotactic proein from virally infected murine fibroblasts; Relationship with the product of the mouse competence (JE) gene," Eur. J. Biochem. 199(1):223-229 (1991).
Van Damme, J. et al., "Structural and Functional Identification of Two Human, Tumor-Derived Monocyte Chemotactic Proteins (MCP-2 and MCP-3) Belonging to the Chemokine Family," J. Exp. Med. 176:59-65 (1992).
Villiger, P.M. et al., "Monocyte Chemoattractant Protein-1 (MCP-1) Expression in Human Articular Cartilage," J. Clin. Invest. 90(2):488-496 (1992).
Wempe, F. et al., "Gene Expression and cDNA Cloning Identified a Major Basic Protein Constituent of Bovine Seminal Plasma as Bovine Monocyte-Chemoattractant Protein-1 (MCP-1)," DNA and Cell Biol. 10(9):671-679 (1991).
Yoshimura, T. et al., "Human monocyte chemoattractant protein-1 (MCP-1); Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE," FEBS Letters 244(2):487-493 (1989).
Yoshimura, T. and Yuhki, N. "Neutrophil Attractant/Activ
Li Haodong
Ruben Steven M.
Sutton, III Granger G.
Human Genome Sciences Inc.
Kemmerer Elizabeth C.
LandOfFree
Human chemotactic protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human chemotactic protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human chemotactic protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1322446