Human chemokine receptor-like protein

Details Human chemokine receptor-like protein Human chemokine receptor-like protein

1997-03-06

1999-09-21

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 231, 536 2431, 4353201, 435325, 4352523, 4351723, C07M 2104, C12N 1512, C12N 1563

Patent

active

059553030

ABSTRACT:
The present invention provides a human chemokine receptor-like, protein (NHCR) and polynucleotides which identify and encode NHCR. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of NHCR.

REFERENCES:
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Raport, C.J. et al., "Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1.beta., and MIP-1.alpha.", J. Biol. Chem., 271: 17161-17166 (1996).
Myers, S.J. et al., "Signal Transduction and Ligand Specificity of the Human Monocyte Chemoattractant Protein-1 Receptor in Transfected Embryonic Kidney Cells", J. Biol. Chem., 270: 5786-5792 (1995).
Taub, D.D., "Chemokine-Leukocyte Interactions, The Voodoo That They Do So Well," Cytokine & Growth Factor Rev., 7: 355-376 (1996).
Murphy, P.M., "The Molecular Biology Of Leukocyte Chemoattractant Receptors", Annu. Rev. Immunol., 12: 593-633 (1994).
Raport, C.J. et al., "New members of the chemokine receptor gene family", J. Leuk. Biol. 59: 18-23 (1996).
He, J. et al., "CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia", Nature, 385: 645-649 (1997).
Raport, C.J. et al., (Direct Submission), GenBank Sequence Database (Accession 992700), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 992700).
Raport, C.J. et al., (Direct Submission), GenBank Sequence Database (Accession U33447), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 992699).

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