Human CGRP

Details Human CGRP Human CGRP

1983-12-23

1985-10-29

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, C07C10352

Patent

active

045499861

ABSTRACT:
Human CGRP (calcitonin-gene-related peptide) has the formula: H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg- Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe -NH.sub.2. Human CGRP or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception. By using human CGRP to generate production of antibodies, it should be possible to diagnose human medullary thyroid carcinoma via immunoassay techniques.

REFERENCES:
patent: 3929758 (1975-12-01), Hughes et al.
Amara et al., "Alternative RNA Processing in Calcitonin Gene Expression Generates mRNAs Encoding Different Polypeptide Products", NATURE, vol. No. 5871, pp. 240-244, Jul. 15, 1982.
Craig et al., "Partial Nucleotide Sequence of Human Calcitonin Precursor mRNA Identifies Flanking Cryptic Peptides", NATURE, vol. 295, Jan. 28, 1982.

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