HUMAN CERVICAL CANCER SUPPRESSOR PROTEIN, POLYNUCLEOTIDE...

Details HUMAN CERVICAL CANCER SUPPRESSOR PROTEIN, POLYNUCLEOTIDE... HUMAN CERVICAL CANCER SUPPRESSOR PROTEIN, POLYNUCLEOTIDE...

2005-12-20

2005-12-20

Nguyen, Dave Trong (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C514S04400A, C424S093100, C435S320100

Reexamination Certificate

active

06977296

ABSTRACT:
The present invention provides a human tumor suppressor protein having the amino acid sequence of SEQ ID NO: 2; a polynucleotide encoding the tumor suppressor protein; an expression vector containing the polynucleotide; a microorganism or animal cell transformed with the expression vector; a method for suppressing proliferation of a cancer cell which comprises introducing the expression vector into a cancer cell to induce apoptosis thereof; and a pharmaceutical composition for preventing or treating cancer which comprises a therapeutically effective amount of the polynucleotide and a pharmaceutically acceptable carrier.

REFERENCES:
Deonarain (1998) Exp. Opin. Ther. Pat., 8(1): 53-69.
Gorecki (2001) Exp. Opin. Emerging Drugs, 6(2): 187-98.
Verma, et al. (1997) Nature, 389: 239-42.
Eck, et al. (1996) Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Ed., McGraw-Hll, New York, NY., pp. 77-101.
Cho, et al. (2002) Yonsei Medical Journal, 43(6): 722-28.
Hughes (2004) J. Surg. Oncol., 85: 28-35.
Accession No. Al702982 of the EST database, published Dec. 18, 1999.
Accession No.: Al339936 of the EST databases published Dec. 29, 1998.

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