Human cell line stably expressing 5cDNAS encoding procarcinogen-

Details Human cell line stably expressing 5cDNAS encoding procarcinogen- Human cell line stably expressing 5cDNAS encoding procarcinogen-

1992-12-28

1995-07-04

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351721, 4351723, C12N 1500

Patent

active

054299489

ABSTRACT:
An immortal human cell line stably expressing a multiplicity of cytochrome P450s is provided. Preferably, the cell line is MCL-5, which stably expresses cytochrome P450 IA1, IA2, IIA3, IIIA4, and IIE1, as well as microsomal epoxide hydrolase. The cell line is useful in mutagenicity, toxicity and metabolism studies.

REFERENCES:
Daves et al Carcinogenes 10(S) 885, 1989.
Crespi et al Mutater & Environment, 97-106, 1990 Wiley-Tess, Inc.
Crespi et al Mol. Carcinogenes 3:58, 1990.
Crespi, C. et al., The development of human cell libes which stably express human cytochrome P450 cDNAs, Environmental and Molecular Mutagenesis, vol. 15, Suppl 17, 1990, p. 14 and 21st Annual Meeting of the Environmental Mutagen Society, Albuquerque N.Mex., Mar. 25-29, 1990, abstract No. 45.
Crespi, E. et al., A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing, Chemical Reaserch in Toxicity, vol. 4, No. 5, Sep. 1991, pp. 556-572.

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