Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-03-19
1998-01-27
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435326, 536 235, 935 22, 935 66, C07H 2104, C12N 1500, C12N 1563
Patent
active
057121150
ABSTRACT:
The present invention provides a polynucleotide which identifies and encodes a human cell death-associated protein (cdap) which was isolated from a rheumatoid synovium library. The invention provides for genetically engineered expression vectors and host cells comprising a nucleic acid sequence encoding CDAP. The invention also provides for the therapeutic use of purified CDAP, cdap or its antisense molecules, or CDAP inhibitors in pharmaceutical compositions and for treatment of conditions or diseases associated with expression of CDAP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
REFERENCES:
Okura et al. (1995) Circulation 92 (8 Suppl.) I-371.
Boldin et al., A Novel Protein that Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain, J. Biol. Chem., 270:7795-7798, 1995, (GI791038).
Cleveland et al., Contenders in FasL/TNF Death Signaling, Cell, 81:479-482, 1995.
Chinnaiyan et al., FADD, a Novel Death Domain-Containing Protein, Interacts with the Death Domain of Fas and Initiates Apoptosis, Cell, 81:505-512, 1995.
Hsu et al., The TNF Receptor 1-Associated Protein TRADD Signals Cell Death and NF-kB Activation, Cell, 81:495-504, 1995.
Stanger, RIP: A Novel Protein Containing a Death Domain That Interacts with FAS/APO-1 (CD95) in Yeast and Causes Cell Death, Cell, 81:513-523, 1995.
Braxton Scott Michael
Hawkins Phillip R.
Murry Lynn E.
Billings Lucy J.
Cech Emma
Chan Christina Y.
Incyte Pharmaceuticals Inc.
Luther Barbara J.
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